Temperatures Make Toxins Tougher to Tolerate
Animals metabolize plant toxins with more difficulty when the heat is on
In a lab experiment, the wood-rat easily tolerates a diet including creosote toxins at lower temperatures; but at only slightly elevated temperatures of 29° Celsius, the animals would refuse to eat the same diet, to the point of rapid and potentially dangerous weight loss. The difficulty probably lies in the metabolic load of processing toxins in the liver, which would cause animals to overheat at higher temperatures.
Since many wild and domestic species eat plants with defensive toxins, this could be a challenge for them in a warming world.