Unlocking Bryson's Brain

 
 

Unlocking Bryson's Brain

Bryson is a beautiful, happy and loving boy. But a mysterious illness means he can't walk, talk, or feed himself. After years without a diagnosis, even Bryson's parents have come to accept that he may never be able to live independently. Then one day, everything changes. Scientists working at the cutting edge of genetics believe they know what's causing Bryson's disease -- and think it could be reversed. Motivated by the hope for a cure, Bryson's parents search for the miracle key that could unlock Bryson's brain.

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Download episodes from this podcast for: 10 years
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Episode 8: Two Futures

After months of waiting, the “Bryson mouse” is finally ready for lab tests that will provide new insights into treatments and cures. And Bryson’s parents explore two possible versions of Bryson’s future.

Download Episode 8: Two Futures
[mp3 file: runs 00:58:53]


Episode 7: Pilgrimage to Boston

Bryson’s parents travel to Boston/Cambridge, the global capital for rare disease research. Their goal: to ask private biotech companies to help in their search for a cure. Scientists provide new clues, but also raise difficult questions.

Download Episode 7: Pilgrimage to Boston
[mp3 file: runs 00:40:44]


Episode 6: The Ethics of Cure

Finding a cure for Bryson no longer seems impossible. And that raises new questions about the ethics of this journey. Bryson’s family seeks out new perspectives and learns why “cure” is a loaded term in the disability rights community.

Download Episode 6: The Ethics of Cure
[mp3 file: runs 00:49:59]


Episode 5: Making a Mouse

Scientists in Toronto get to work building a mouse with Bryson’s precise genetic variant. Plus, the family travels to Atlanta to provide blood samples for a researcher to create DNA-based “mini-brains” in his lab. Could this cutting edge science provide clues to unlocking Bryson’s brain?

Download Episode 5: Making a Mouse
[mp3 file: runs 00:43:01]


Episode 4: A New Hope

Bryson’s family travels to meet other GRIN1 patients, including Bryson’s GRIN-twin Olivia. And research on mice offers new hope for finding a cure. But a new illness means that the family now needs two medical miracles.

Download Episode 4: A New Hope
[mp3 file: runs 00:53:05]


Episode 3: The CRISPR Revolution

Bryson’s parents explore CRISPR, a new technology with the potential to cure dozens of diseases once thought incurable. But gene editing comes with risks — not just for individual patients, but for the human race.

Download Episode 3: The CRISPR Revolution
[mp3 file: runs 00:33:39]


Episode 2: Getting a Diagnosis

From violent seizure-like episodes to insensitive comments from strangers, Bryson has a hard life. But after years of searching, doctors finally provide a diagnosis. The news changes everything for Bryson’s parents and provides a possible path to new treatments — or even a cure.

Download Episode 2: Getting a Diagnosis
[mp3 file: runs 00:45:03]


Episode 1: The Mystery Disease

Bryson seems like a perfectly healthy baby. But soon doctors confirm his parents’ worst fears: something is wrong with Bryson’s brain. Despite dozens of tests over nearly a decade, doctors come up empty in their efforts to find a diagnosis.

Download Episode 1: The Mystery Disease
[mp3 file: runs 00:53:59]


Unlocking Bryson's Brain - Trailer

Bryson is a beautiful, happy boy. But a mysterious illness means he can’t walk, talk, or feed himself. Scientists working at the cutting edge of genetics believe they know what’s causing Bryson’s disease — and think it could be reversed. Motivated by the hope for a cure, Bryson’s parents search for the miracle key that could unlock Bryson’s brain. Hosted by Keith McArthur, coming April 2020.

Download Unlocking Bryson's Brain - Trailer
[mp3 file: runs 00:03:45]