Prostate, lung cancer ID filter created at University of Waterloo
Prof. Alex Wong says digital 'fingerprint' will make it easier to identify cancer on MRI, CT scans
New research out of the University of Waterloo could take some of the guesswork out of reading MRI and CT scans.
Alex Wong, a professor of system design engineering, has discovered unique bio-markers that could help radiologists better identify prostate and lung tumours on medical images.
Diagnosing cancer through an imaging screening is a very difficult process. It's actually very tough.- Alex Wong, University of Waterloo
"You could treat it as creating a digital fingerprint for characterizing tissue," Wong said, one that can be compared to a patient's MRI or CT scan.
"If this particular fingerprint matches that of, let's say, a malignant tumour, then a radiologist can look at this and say, 'Well, these are very similar. Maybe this is something we should look further into.'"
Creating a fingerprint
Wong developed his fingerprints by feeding hundreds of pages of medical images into a computer, and then designing a program that would look for similarities. In this way, he was able to identify the characteristics unique to images of certain tumours.
The pictures don't really give a full story.- Alex Wong, University of Waterloo
"We can then extract this information – this quantitative, biomark information – and put it in front of the radiologist, so that they have a much better way of analyzing whether or not it's cancer."
Wong said this discovery would change the way radiologists examine medical images. He says the current method involves a lot of guesswork, relying on experience and expertise rather than computer-assisted interpretation.
"Radiologists are very skilled clinicians that do their best," he said. "The problem here is diagnosing cancer through an imaging screening is a very difficult process. It's actually very tough, despite the fact they have many, many years of experience looking at it.
"That's mainly because just visually the pictures don't really give a full story. So, what ends up happening is a radiologist has to rely on their many years of expertise, knowledge of anatomy and tissue, and doing an educated guess as to what they're looking at."
'We might discover things that people haven't thought of before."- Alex Wong, University of Waterloo
The result is that many tumours are correctly identified, but some are not.
"From a visual perspective, some of these differences between a malignant tumour and healthy tissue and benign tumours are so subtle that ... there are certain situations where just looking at the MRI itself you might not even be able to visually see it, and that leads to misdiagnosis."
Wong said digital fingerprints of different tumours will make it easier for radiologists to accurately identify tumours, ensuring that there is more consistency in cancer diagnosis.
The system is also helping scientists better understand the physiology of prostate and lung cancers.
"By leveraging this wealth of information, what we might be able to do – and what we're starting to do – is we might discover things that people haven't thought of before," he said.
His system is being tested and refined at Sunnybrook Health Sciences Centre in Toronto, and he hopes it will be commercialised in the future.