'Everything is interrelated': Scientists write family tree for tree of life
The work is already yielding concrete benefits, researchers say
Scientists have written the family tree for the tree of life.
Researchers from around the world, including some from several Canadian universities, say it took nine years of work to analyze the genetics of 1,100 plant species from algae to elm trees.
That work, published Wednesday in the journal Nature, has allowed them to pinpoint a billion years of evolutionary relationships between plants as different as cannabis and cucumbers, orchids and oaks.
"Everything is interrelated," said the University of Alberta's Gane Wong, one of the paper's dozens of co-authors.
Science has long known that species with significant differences can be related through a common evolutionary ancestor. In plants, those relationships have been studied mostly by asking questions such as: do they have trunks or flowers?; or, how do their seeds form?
'Going all the way back to algae'
Wong and his colleagues — nearly 200 of them — have been looking at how links are expressed through genetics. They isolated and sequenced genetic RNA material from 1,124 different plant species.
They took care to select a wide variety of plant types.
"We wanted to look at how plants evolved," said Wong. "This is going all the way back to algae. One of the things biologists constantly argue over is which came before what? How did this species evolve?"
New species are created when a mutation begins splitting one species into two. Eventually, those two also mutate, which leads to another two, and so on, until there's a vast branching tree of life with a half-million different plant species in it.
Wong and his colleagues wondered if the record of those ancient mutations would be preserved in the RNA.
"Can we, from the RNA sequence, draw this tree of life for all 1,000 species?" asked Wong. "For 95 per cent or so, the answer is, yes, we can do it quite well, and probably better than you could do by just looking."
The computing power needed was significant. Data to be analyzed was measured in terabytes, where one terabyte equals 1,000 gigabytes.
Even then, the team couldn't resolve everything. They couldn't find branches in the tree for about five per cent of species, either because there wasn't enough data or because it dated from so long ago it couldn't be read accurately.
"We're talking about events that happened a billion years ago."
But the work is already yielding concrete benefits. Proteins taken from an obscure algae species studied by the researchers were found to turn certain brain neurons on and off. Those proteins are now being used in clinical trials to treat blindness.
It's proof of the value of basic research, said Wong. It's also proof of the value of nature, which has been solving problems and getting things done for a long, long time.
"It's all based on exploring the diversity of life, because evolution or nature has solved a lot of important problems," Wong said.
"Sequencing is a way to learn about it. It's trying to learn to use all the lessons that have been learned by nature over billions of years."