Montreal's Eugenie Bouchard advanced to the third round of the Family Circle Cup on Tuesday, a day which saw No. 1 Serena Williams lose to the 78th ranked player in the world.

Bouchard, seeded sixth in the tournament, drubbed Russia's Alla Kudryavtseva by scores of 6-2, 6-0 in Charleston, S.C.

The Westmount, Que., native needed just 58 minutes to get past a player who once reached the fourth round of Wimbledon, but has slipped to 117th in the world. Bouchard is ranked 20th.

Bouchard, who received a bye into the second round, will next play the winner of a match between Venus Williams of the United States and Scheepers of South Africa.

Venus's younger sister, Serena, was shocked 6-4, 6-4 by Jana Cepelova of Slovakia. Cepelova, who's never made it past the third round of a Grand Slam, came into the week ranked 78th in the world.

Serena Williams was coming off her seventh Sony Open title last week, which was capped off a by a win over Li Na.

'I'm really just dead. I need some weeks off where I don't think about tennis and kind of regroup.'- World No. 1 Serena Williams

"I'm really just dead. I need some weeks off where I don't think about tennis and kind of regroup," Williams said after the match. "I've had a long couple of years, and I'm really a little fatigued."

Williams, the top seed and defending champion in Charleston, was looking for her second straight title and her third this year after winning a record seventh Sony Open last weekend.

But with only 18 minutes gone in the match, she was down 0-5 on the green clay at the Family Circle Tennis Center. Williams rallied, winning four straight games surrendering only six points and it looked like Cepelova's lead would be short-lived. But the 20-year-old Cepelova came back and, holding serve in the final game, was able to win the set.

Williams said later she feels emotionally and physically spent.

"Definitely a little bit of both. But again, I think Jana played really well for her today," she said. "The good thing is I know I can play a lot better. So it's always really positive for me."

Cepelova's run out to a quick lead silenced the crowd, which was in the defending champion's corner

"I have 5-0 and I was a little bit nervous, but I did it," said Cepelova. "You know, you play against No. 1 player and you never know. It was a tough situation for me, but I'm really happy that I keep the set."

An ailing Venus Williams needed three sets to edge Barbora Zahlavova Strycova 6-3, 0-6, 7-5 in the first round of the Family Circle Cup on Tuesday.

"I've actually been pretty sick lately — I've been having like a bug," she said after the match that lasted two hours, 15 minutes on the green clay. "You just have to play your way into the week and just continue to feel better."

The seven-time Grand Slam champion has battled injuries and Sjogren's syndrome, a fatigue-causing autoimmune disease, during the past two years.

"I haven't gotten rid of it. I wish I could have. Unfortunately it just clings to me," Williams said. "I've just learned to handle it mentally and also I try to do things all the time, just always going for optimal health."

No. 8 Cirstea bounced

Also Tuesday, No 9. seed Lucie Safarova of Czechoslovakia defeated Virginie Razzano of France 2-6, 6-4, 6-4.

American Vania King beat Julia Glushko 4-6, 7-5, 6-3, and Daniela Hantuchova of Slovakia defeated American wild card Shelby Rogers 7-5, 7-5. No. 13 Elena Vesnina of Russia cruised past Anna Schmiedlova of Slovakia, 6-2, 6-1, and Shuai Zhang of China outlasted Su-Wei Hsieh of Taiwan 3-6, 7-6 (5), 7-6 (0).

In other matches, No. 14 seed Andrea Petkovic of Germany eliminated Lesia Tsurenko of the Ukraine, 6-7 (2), 6-4, 6-1, and Spain's Lourdes Dominguez Lino defeated countrywoman Anabel Medina Garrigues 6-3, 6-2. Peng Shuai of China defeated Caroline Garcia of France 6-2, 6-3.

No. 7 seed Samantha Stosur of Australia eliminated Yaroslava Shvedova of Kazakhstan 6-3, 5-7, 6-1, while Teliana Pereira of Brazil ousted eighth-seeded Sorana Cirstea of Romania 3-6, 6-3, 7-6 (0). Marina Erakovic of New Zealand defeated Nadia Petrova of Russia, who received a wild card for the tournament, 4-6, 6-3, 6-4.

With files from CBCSports.ca