Gilles Muller of Luxembourg knocked off No. 8-seeded Milos Raonic in the first round, edging the Canadian 7-5, 7-6 (1) in Valencia Open tennis action.
John Isner of the United States lost to David Goffin 7-6 (2), 4-6, 6-4 in the second round.
Isner had 21 aces but it wasn't enough against his Belgian opponent, who has improved in the rankings to 45th from No. 175.
Isner has gone 4-5 since winning at Winston-Salem in August. The loss hurts his bid to qualify for the World Tour Finals next month, with only the Paris Masters left to play before the season-ending event.
Seventh-seeded Marin Cilic joined Goffin in reaching the quarterfinals with a 6-1, 6-4 victory over Fernando Verdasco, with fellow Croatian Ivan Dodig also winning his second-round match, a 6-1, 3-6, 6-2 win over Australian veteran Lleyton Hewitt.
Also, reigning champion Marcel Granollers of Spain also beat Czech qualifier Jan Hajek 7-5, 6-4 to advance to the second round.
Federer advances at Basel
Roger Federer edged Thomaz Bellucci of Brazil 6-3, 6-7 (6), 7-5 Wednesday to advance to the quarterfinals of his hometown Swiss Indoors tournament.
The top-ranked Federer saved four consecutive set points in the second-set tiebreaker in Basel before the 34th-ranked Bellucci tied the second-round match.
It was not until match point that Federer, who held serve throughout, had the decisive break-point chance in the decider.
Federer will face either Benoit Paire of France or Lukasz Kubot of Poland in the final eight Friday. Paire beat fifth-seeded Andreas Seppi of Italy, 4-6, 6-2, 6-3.
Also advancing to the quarter-finals was third-seeded Richard Gasquet of France who beat Federer's boyhood friend Marco Chiudinelli, 6-1, 6-4. Grigor Dimitrov of Bulgaria had 17 aces in defeating France's Julien Benneteau 7-6 (5), 6-7 (1), 7-6 (3).
In other first-round action, second-seeded Juan Martin del Potro of Argentina eased past Alejandro Falla of Colombia 6-4, 6-1, and Marinko Matosevic of Australia upset seventh-seeded Florian Mayer of Germany 6-2, 6-3.