Milos Raonic is the lone Canadian left in singles at the U.S. Open.

Raonic advanced to the third round with a 6-1, 6-2, 6-4 victory over Spain's Pablo Andujar on Thursday.

The 10th-seeded Thornhill, Ont., native fired a modest nine aces, with Andujar saving match points in the last two games. Raonic served it out a game later to take the win on his sixth winning opportunity with a deep forehand to the corner after just over two hours.

The 22-year-old is quietly looking ahead to what he hopes will be continual improvement at the final major of the season.

"I'm playing really well. I created a lot of opportunities for myself, especially on his serve," said Raonic. "But I can serve better, so that gives me a day to work on it. It gives me a lot of confidence and a lot of belief in myself."

Raonic will next face Feliciano Lopez after the Spaniard defeated American Bradley Klahn 6-4, 7-6 (7-4), 4-6, 7-5. Raonic's best results at a major were a pair of fourth-round exits at the Australian Open and in New York in 2011.

Earlier in the men's side, Spain's Tommy Robredo defeated Frank Dancevic of Niagara Falls, Ont., 6-4, 6-4, 6-1.

There were no survivors for Canada on the women's side. Montreal's Eugenie Bouchard fought off four match points before losing 6-4, 2-6, 6-3 to eighth-seeded Angelique Kerber.

Canada is still competing in men's doubles. Toronto's Daniel Nestor and Vasek Pospisil combined for a first-round win, beating India's Mahesh Bhupathi and German Philipp Petzschner 6-3, 7-6 (7-4). It's Nestor's first Grand Slam since splitting from Swede Robert Lindstedt this month.

Nadal keeps rolling

Earlier on the men's side, Rafael Nadal made quick work of his second-round opponent, taking the final 12 games in his 6-2, 6-1, 6-0 victory over qualifier Rogerio Dutra Silva.

Second-seeded Nadal improved to 17-0 on hard courts this year. He has lost only 11 games over his first two matches of the tournament.

The Brazilian fought Nadal for a brief time and even had a break point in the second game of the second set.

But Nadal saved the break point, and closed out the first of the dozen straight games to close the match and stay on course for a quarter-final meeting with long-time foe Roger Federer.

Federer breezes into 3rd round

Five-time U.S. Open champion Federer posted a 6-3, 6-2, 6-1 victory over Argentina's Carlos Berloq in 95 minutes.

Federer is seeded seventh at Flushing Meadows, his worst since 2002. But he hasn't dropped a set through two victories.

"It's one of those matches I expect myself to win if possible in straight sets and gain confidence in the process," Federer said. "All those things happened, so, yeah, I'm pleased about it."

The 48th-ranked Berlocq has never made it past the second round at a Grand Slam event and is 0-17 against top-10 opponents

Fourth-seeded David Ferrer overcame a shaky second-set tiebreaker to defeat fellow Spaniard Roberto Bautista Agut 6-3, 6-7 (5), 6-1, 6-2.

In doubles, the Bryan brothers, Bob and Mike, opened their quest to complete the calendar Grand Slam with a 7-6 (1), 6-2 win over Federico Delbonis and Leonardo Mayer of Argentina.

Isner gets past Monfils

John Isner heard U.S. Open fans surprisingly supporting his French opponent, Gael Monfils. Isner, the highest-ranked American man, felt pain in his upper right leg. And, maybe worst of all, Isner saw his lead slipping away.

Overcoming it all, the 13th-seeded Isner held on to beat the 39th-ranked Monfils 7-5, 6-2, 4-6, 7-6 (4) to reach the third round for the fifth consecutive year.

From late in the third set, spectators at Louis Armstrong Stadium occasionally chanted "Let's go, Monfils!" or loudly sang his last name during breaks between points. They rose to their feet and raucously saluted Monfils' best shots. They applauded faults and other errors by Isner.

"It was surprising, actually," Monfils said. "It was surprising — but it was good."

Certainly was an unusual display: plenty of vigorous cheering for a non-American while he played an American at the country's most important tennis tournament. Maybe, as Monfils guessed afterward, the ticket-holders simply wanted more bang for their buck, instead of a three-set, open-and-shut affair. Or maybe, as Isner surmised, Monfils' style just won them over.

"He's a very fun-loving guy, and he gets cheered on wherever he goes, not just in France. He's one of the most exciting tennis players in the world, hands down," Isner said. "He's been fighting a bunch of injuries, so it's good to see him back healthy."

Querrey upset by Mannarino

No. 26-seeded Sam Querrey was upset in his second-round match.

Adrian Mannarino beat the American 7-6 (4), 7-6 (5), 6-7 (5), 6-4. The 63rd-ranked Frenchman reached the fourth round at Wimbledon this year.

Querrey's best run at Flushing Meadows was making the fourth round in 2008 and '10. He advanced to the third round at the Australian and French Opens this year.

There were only three breaks of serve in the match, but Mannarino got one at 5-4 in the fourth set to clinch the victory.

Querrey had 25 aces but seven double-faults. The players combined for 117 winners and 106 unforced errors.

With files from The Associated Press