Second-ranked Li Na started her Madrid Open campaign with a victory on Monday, overcoming a stubborn opponent just as third-seeded Agnieszka Radwanska did to reach the second round.

Na's clay debut began with an encouraging 6-1, 7-6 (7) victory over Belgium's Kirsten Flipkens before Radwanska also advanced thanks to a 7-6 (3), 6-2 win over Canada's Eugenie Bouchard.

Li, the Australian Open champion, survived two set points by Flipkens, and eventually took the tiebreaker to avoid another surprise first-round exit like last year. Li goes up against fellow Chinese player Zheng Jie next.

Bouchard, Li's opponent in the Australian Open final, came out on the losing end of a tough match against third-ranked Radwanska, as the Polish player earned her 25th match win of the season.

"The tiebreak was the biggest key," said Radwanska, who goes on to play Svetlana Kuznetsova. "I did a couple of good shots in the tiebreak and managed to win that, and that gave me more confidence in the second set."

Kuznetsova held off Alize Cornet of France 6-3, 4-6, 6-1 as the Russian continued her good run, including reaching the final in Portugal on Saturday.

Also, Caroline Wozniacki was a 6-2, 6-2 victor over Ekaterina Makarova.

A minute's silence was scheduled to be held at the Magic Box's Manolo Santana center court before the evening match in remembrance of Elena Baltacha, a former top-50 British women's player who died of liver cancer on Sunday.

In men's first-round play, ninth-seeded John Isner beat Russian qualifier Teymuraz Gabashvili 7-6 (8), 6-4, with the American securing the only break in a match heavy on baseline groundstrokes.

Kei Nishikori followed up his Barcelona Open triumph with a 6-4, 6-4 win against Ivan Dodig of Croatia.

Nishikori said working with former French Open champion Michael Chang boosted his confidence on this surface as he won his first career clay title in Barcelona.

"I'm playing well and did well last week in Barcelona and I'm getting better on clay so hopefully I can go further this week," the 12th-ranked Japanese player said. "There was just one bad game, on my serve at 3-2 in the second set. Otherwise, it was an almost perfect match."

Jo-Wilfried Tsonga beat Edouard Roger-Vasselin 6-3, 4-6, 6-3, while Gilles Simon emerged from another all-French matchup, after Benoit Paire retired, to play Roger Federer next.

Stanislas Wawrinka, who is looking to follow-up his Monte Carlos Masters triumph, opens in the Spanish capital against Dominic Thiem after the Austrian beat Dmitry Tursunov of Russia 6-4, 6-2. Other winners were Mikhail Youzhny of Russia, Jarkko Nieminen of Finland, and Spanish players Fernando Verdasco and Feliciano Lopez.