Top-seed and two-time defending tournament champion Milos Raonic of Canada had 14 aces in a 7-6, 6-3 win Friday over Uzbekistan's Denis Istomin to advance to the SAP Open semifinal in San Jose, Calif.

John Isner reached the semifinals for the first time in his career, rallying in a first-set tiebreaker before overpowering Xavier Malisse 7-6 (8), 6-2 behind his booming serve.

The highest-ranked American saved two break points in the lengthy tiebreaker, relied on his big-finish forehand for two breaks in the second set and never let his strong serve slip during a quick 68-minute match. He will play Saturday against fourth-seeded Tommy Haas, who beat wild-card Steve Johnson 6-4, 6-2.

Third-seeded Sam Querrey faced Colombia's Alejandro Falla in the late match.