Holding a three-shot lead, Bryant birdied his first two holes en route to a three-under-par 67 in Atlanta, Ga.
He finished at 17-under- 263 to win by six strokes at East Lake Golf Club.
"This goes so far beyond all of my expectations," admitted Bryant, who pocketed $1,170,000 US for the win. "It's just amazing and a real dream come true."
Bart Bryant holds his golf glove as he waits for Retief Goosen to putt on the sixth green on Sunday. (AP Photo/John Bazemore)
It was a record-setting week for Bryant that started with a course-record 62 on Thursday. He established a new 54-hole mark on Saturday, then obliterated Phil Mickelson's former tournament record by four shots.
The win was Bryant's third in the last 18 months. He captured the 2004 Texas Open, and earlier this season won the Memorial.
Tiger Woods finished as the runner-up in this event for the third time. He managed a one-under 69 on Sunday to come in a distant second at 11-under-par 269.
"It was up to us to try and go get him," said Woods, who won the 2005 PGA Tour money title with over $10 million. "He wasn't going to come back to us. We didn't do that today."
Scott Verplank shot a one-under 69 and finished alone in third place at minus-nine. Retief Goosen, who was in second place after the third round, struggled to a four-over 74 on Sunday. He tied for fourth place with Vijay Singh (67) and Davis Love III (69) at seven-under-par 273.
Any challenger had to feel disheartened when the 42-year-old Bryant played the first hole.
Bryant knocked his approach at No. 1 to six feet and ran home the birdie putt.
He made it two in a row at the second to post a five-stroke cushion.
Leading by four at the par-5 ninth, Bryant's second landed in a greenside bunker, but he blasted out to seven feet and converted the birdie attempt.
Woods birdied nine, 10 and 12, but Bryant answered the challenge from the No. 1 player in the world.
He ran into some trouble at the par-5 16th hole, sailing his second shot over the green that landed against a fence. Bryant advanced his next shot to the fringe and could not get up and down for par.
But Woods was unable to take advantage and fell six strokes back.
Bryant played to the safest places on the greens at 16 and 17 and walked off with pars. His tee ball on the par-3 18th went through the green, but Bryant chipped to two feet and stroked home the par putt.
