Ian Watmore quit as chief executive of the English Football Association on Monday after only nine months in the job after apparently growing frustrated at the inability to push through changes within the organization.
Watmore's resignation comes less than three months before the World Cup begins and leaves the FA looking for its fifth chief executive in 10 years.
While he had no direct role in England's bid to host the World Cup in 2018 or '22, the fallout from Watmore's sudden departure will not help the campaign ahead of December's vote.
Watmore didn't publicly discuss his reasons for leaving, but was widely known to have grown increasingly frustrated about his lack of power, with individuals within the FA structure apparently blocking his attempts to transform the governing body.
Watmore was also reportedly unhappy with the power held by Premier League chairman Dave Richards, who sits on a number of important FA committees including the board.
FA chairman David Triesman, who had a good working relationship with Watmore, said he had tried to persuade the former civil servant to stay.
"Ian Watmore tendered his resignation to me on Friday," Triesman said. "I asked him to reconsider over the weekend. However, he has confirmed today that his position remains unchanged and I have accepted it with great regret.
"There will be a board meeting [Tuesday] at noon. I am unable to make any further comment until after that meeting."
Watmore's predecessor, Brian Barwick, quit in August 2008 after disagreements with Triesman over the scope of his role but stayed until the end of that year.
Watmore's main achievement was reviving plans for a permanent training base for the national team to emulate France's Clairefontaine complex -- eight years after it was first announced.