Pablo Vitti and Dwayne De Rosario scored as Toronto FC blanked the New York Bulls 2-0 in front of 20,902 raucous fans at BMO Field on Wednesday night.
Toronto FC (6-5-4) vaulted into second place in the MLS Eastern Conference, one point behind D.C. United.
It marked Toronto's second triumph in less than two weeks over the Red Bulls, who remain winless on the road in 21 straight matches (0-15-6) — an MLS record.
The Red Bulls (2-11-4) haven't won on the road since surprising the Los Angeles Galaxy 2-1 on May 10, 2008.
"I don't think it was a great game," Toronto FC interim head coach Chris Cummins said. "It was bit lacklustre in the first half.
"But I thought it was a very good professional performance from the lads."
Toronto FC was fresh off their finest offensive outing in franchise history, a 6-1 romp over the Montreal Impact that clinched the Voyageurs Cup for the Reds and the right to represent Canada in the CONCACAF Champions League.
Prior to that, Toronto FC had never scored more than four goals in a match.
"We're bound to catch a little streak," Toronto FC defender Adrian Serioux said. "We're going to take this ball and keep on running."
Vitti, a flamboyant forward from Argentina, opened the scoring 28 minutes into Wednesday's match.
Toronto FC midfielder Nana Attakora chipped the ball neatly over a startled Red Bulls defence with the outside of his right foot to Vitti, who settled it and nodded it over keeper Danny Cepero for his first MLS goal.
"Finally, when the goal comes, it is satisfaction," said Vitti, who hadn't scored in 13 matches.
"Delighted for Pablo to net his first goal," Cummins said. "He is over the moon, obviously, himself.
"He said, 'I can relax now.' I told him he can't."
Vitti narrowly missed making it 2-0 as he snuck between two defenders and slipped a rebound between Cepero's legs, only to watch the ball trickle wide of the post.
Moments later, De Rosario spun in the box and unleashed a shot that was blocked at the goal-line by Red Bulls defender Andrew Boyens, formerly of Toronto FC.
Toronto FC appeared to strike again in the 52nd minute when forward Chad Barrett tucked De Rosario's centring pass inside the post, but the play was ruled to be offside.
Seven minutes later, De Rosario took Barrett's left-footed cross off his chest and lobbed it over Cepero for his fifth goal of the campaign.
"I think leading up to that, we had a nice little sequence of possession," De Rosario said. "Chad touched it inside — a great ball over the top with his left foot — and I saw the keeper edging out and he kind of paused and I just flicked it over him."
Attakora had a hand in the play, as well.
"He was outstanding again," Cummins said. "He can either play centre-half or can play right back and, you see the kid, he is just improving all the time."
Amado Guevara and Serioux started for Toronto FC, despite being hobbled by tender ankles.
Serioux and Red Bulls forward Dane Richards received yellow cards for a shoving match in the 77th minute.
Of note, Toronto FC wore pink jerseys in support of the Canadian Breast Cancer Foundation.