Switzerland's team doctor says defender Philippe Senderos will miss the squad's two remaining group matches because of an ankle injury.
Senderos sprained his right ankle in Wednesday's 1-0 upset win against Spain.
Team doctor Cuno Wetzel said X-rays and magnetic scans Thursday showed no fractures but a "painful distortion of his ankle."
"He will be out for the next two games," Wetzel said at the team camp in Vanderbijlpark.
Senderos was substituted after 36 minutes in Switzerland's 1-0 win against European champion Spain. Midfielder Gelson Fernandes scored the winner.
Senderos is joining Fulham from Arsenal on a three-year contract.
The 25-year-old center back moved to Arsenal from Swiss side Servette in 2003, but struggled to win a regular starting place and joined Everton on loan for the second half of last season. He will join Fulham after his Arsenal contract expires at the end of this month.