Cristiano Ronaldo reacts Wednesday to Real Madrid's ouster. ((Denis Doyle/Getty Images))

Big-spending Real Madrid was eliminated by Lyon in the second round of the European Champions League with a 1-1 tie Wednesday night, and Manchester United advanced to the quarter-finals with a 4-0 rout of AC Milan and David Beckham.

At Madrid, Cristiano Ronaldo put the home team ahead in the sixth minute, but Miralem Pjalic tied it in the 75th and Lyon won the home-and-home, total-goals series on 2-1 aggregate.

Real Madrid, a nine-time champion, spent about $350 million US last summer to acquire Ronaldo, Kaka, Karim Benzema and Xabi Alonso in a bid to regain the European title it last won in 2000. This season was especially important to the club because Real Madrid's Estadio Santiago Bernabeu is host to the Champions League final on May 22.

At Manchester, Wayne Rooney scored twice in Beckham's return to Old Trafford, and Park Ji-sung and Darren Fletcher had one goal each as Manchester United breezed to a 7-2 aggregate win over the seven-time champions. Rooney also scored twice in the first leg and has 30 goals this season.

Beckham entered in the 64th minute and was given a standing ovation in his first match against United at Old Trafford since leaving seven years ago.

"It was nice to be back and obviously a disappointiang night," he said. "It was an unbelievable reception and I have to say thank you."

Rooney headed in a cross from Gary Neville in the 13th minute, then beat goalkeeper Christian Abbiati to a cross from Nani to chip home in the 46th. Park scored off a feed from Paul Scholes in the 59th, and Fletcher headed Rafael da Silva's cross over Abbiati in the 87th.

United fans kept up their protests against the Glazers, who have encumbered the three-time European champions with a $1.1 billion debt since taking over the club in 2005.

Across the stadium, many in the crowd of 74,595 held up protest scarves in the green and gold of Newton Heath, the original incarnation of United, rather than club's colours of red and black. Beckham left the field wearing one of the protest scarves.

Near the end, supporters continuously chanted: "We want Glazers out!" and unfurled "Love United, Hate Glazer" banner.

Arsenal and Bayern Munich advanced to the quarter-finals on Tuesday.

Next week, Inter Milan and coach Jose Mourinho take a 2-1 lead to Chelsea, CSKA Moscow is at Sevilla tied 1-1, Barcelona hosts Stuttgart tied 1-1 and Bordeaux is home to Olimpiakos with a 1-0 lead.