Chelsea captain John Terry was ruled out of the Club World Cup on Friday because of ongoing injury troubles.
The defender damaged ligaments in his right knee a month ago and doctors fear the long flight to Japan could hinder his recovery.
"The inflammation during the flight will not be the best thing for him, so he will not travel," Chelsea manager Rafa Benitez said. "He wanted to go and to help, but it's better that he stays here.
"We don't know when he will play. We have to wait and see how he reacts."
Chelsea's first game at the Club World Cup is Wednesday's semifinal match against either Ulsan Hyundai or Monterrey in Yokohama.
Chelsea earned its spot at the Club World Cup by winning the European Cup for the first time in May.
But 200 days after winning the Champions League, Chelsea became the first holders to go out in the group stage on Wednesday.