There will be little love between neighbours when Real Madrid and Atletico Madrid play in the Champions League final on Saturday.

The Spanish teams make up the first Champions League final between city rivals in history, with the match to be played in nearby Lisbon, Portugal.

Real Madrid is the competition's most successful club and bidding to end a 12-year wait for "La Decima,” its 10th European Cup title. But Atletico is proving to be quite a spoiler this season, winning the Spanish league title over Barcelona last weekend and now one win away from completing the greatest season in the club's 111-year history.

Here are five things to know about Saturday's match:

Injury worries

Cristiano Ronaldo is expected to return from injury to play Saturday. Diego Costa is unlikely.

Advantage, Real Madrid.

Ronaldo has been burdened by leg injuries over the past two months but said Tuesday he would be available to play in his first Champions League final for Madrid. Costa has also endured leg setbacks and, after hobbling off against Barcelona on Saturday, sought treatment from a specialist in Belgrade using horse placenta.

Ronaldo's return will bolster Madrid's already potent attack with Gareth Bale set to start. But striker Karim Benzeman appears to be doubtful with a hamstring injury. Madrid centre back Pepe is also a game-time decision.

Alonso’s replacement

Xabi Alonso's absence deals an important blow to Madrid's midfield.

The Spain international has been one of Madrid coach Carlo Ancelotti's most important players this season, but a yellow card in the semifinal win over Bayern Munich has left him suspended.

Either Sami Khedira, Asier Illarramendi or Casamiro is likely to fill the void and take responsibility for opening up Madrid's attack and breaking up Atletico's buildups.

Illaramendi is the natural successor to Alonso, but he has had a nervy debut season at Madrid.

"It will be a very equal match and I imagine the midfield will be determinant in setting up play," Atletico coach Diego Simeone said.

Villa experience

Not only will David Villa's goal-scoring prowess make up for Diego Costa's absence, but the Spain striker's experience should prove invaluable to an Atletico team short of Champions League experience.

Villa is the only regular in the squad who has played in a Champions League final before, scoring in Barcelona's 3-1 triumph over Manchester United at Wembley Stadium in 2011.

Costa's absence could also bolster Villa's hopes of playing for Spain at the World Cup.

Madrid can count on more experience as Cristiano Ronaldo won the title while at Manchester United and goalkeeper Iker Casillas was part of Madrid's winning teams in 2000 and '02.

Madrid can also draw on the experience of assistant coach Zinedine Zidane, who scored an iconic goal in Madrid's 2-1 win over Bayer Leverkusen in its last Champions League final appearance.

Paisley’s record

Carlo Ancelotti has been able to get Real Madrid where Jose Mourinho never could, and now the Italian coach is one win away from matching Bob Paisley with his third European Cup.

Ancelotti, who also won two European Cups as a player, secured the Champions League at AC Milan in 2003 and '07, leaving him on the verge of matching the former Liverpool manager's record number of titles.

"There's no pressure on me, just the joy of living this moment of happiness," Ancelotti said. "A lot of [teams] have to watch this game in front of the TV and we're lucky to be able to play it. I've watched this game on TV a lot of times and I didn't enjoy it."

Diego Simeone could become just the third non-European coach to win the trophy. The only other two were also Argentine, Real Madrid's Luis Carniglia in 1958 and '59 and Helenio Herrera of Inter Milan in 1964 and '65.

Derby time

Saturday's match represents the most important Madrid derby after 194 league and Spanish Cup games.

Madrid has the advantage with 102 victories to Atletico's 46. Atletico only ended a 14-year unbeaten run against Madrid in all competitions last season when it won the Copa del Rey at the Santiago Bernabeu Stadium.

Atletico has won and drawn the two league encounters since, while Madrid easily won a pair of Copa del Rey matches against Atletico en route to the domestic cup title.

The pair have met in the European Cup once before - in 1959, when Madrid needed a replay to emerge victorious.

After the two legs finished 2-2, Madrid won 2-1 in Zaragoza to reach the final. But in one-game cup finals, Atletico, which can become the seventh team to finish the competition undefeated, leads the series 4-1.

"There are no secrets for this game," Ancelotti said. "The two teams know each other well."