Uruguay striker Luis Suarez scored in the first half after being named to the starting lineup against England in their World Cup Group D match in Sao Paulo on Thursday.
Suarez, who was recovering from knee surgery and missed Uruguay's opening loss to Costa Rica, partners with Edinson Cavani in attack, with Diego Forlan dropping to the bench.
Uruguay coach Oscar Tabarez also brings in Alvaro Pereira, Jose Maria Gimenez, Nicolas Lodeiro and Alvaro Gonzalez in five changes to the side who slumped to a 3-1 loss to the Costa Ricans.
With defender and captain Diego Lugano missing out due to injury, Tabarez named Diego Godin as skipper for the game at the Corinthians arena. The Uruguayan defence is also missing Maxi Pereira, who was sent off against Costa Rica.
Suarez scored 31 goals in 33 games for Liverpool in the English Premier League last season and his return will be a major boost for the South Americans, who finished fourth at the World Cup in South Africa in 2010.
England coach Roy Hodgson has been preparing his side with the expectation of facing Suarez, so the news will come as no real surprise.