Reigning Canadian pairs champions Anabelle Langlois and Cody Hay withdrew Friday from the Oct. 30-Nov. 2 Skate Canada event in Ottawa.
Meanwhile, Canadian singles skater Christopher Mabee announced he's taking the season off.
Langlois, 27, underwent surgery in July to repair a spiral fracture in her lower right fibula suffered during a practice session. She received a clean bill of health from her surgeons on Oct. 9, but is still a few weeks away from resuming a full training load.
The native of Gatineau, Que., hopes to be ready for the NHK Trophy competition in Japan at the end of November.
"We have to play the cards that are dealt to us and this year that means focusing all our energy on coming back strong for nationals," Langlois said. "Cody has kept himself busy on the ice and especially in the gym, trying to keep himself in the best shape possible, while I have had some of the best therapists and doctors help put me back together."
The Canadian team of Mylène Brodeur and John Mattatall will replace Langlois and Hay at Skate Canada.
Mabee, from Tillsonburg, Ont., said he's withdrawing from this season's International Skating Union Grand Prix series, and won't compete at the 2009 Canadian championships.
"I have decided to take this season off to sort out my priorities," said Mabee, 23. "I have been involved in skating for so long that I need a break to regain my focus and figure out what my goals are.
"This doesn't mean that I am not still focused on the Olympics in 2010. That is still a goal of mine that I hope to achieve."