Devils left wing Zach Parise was sent back to New Jersey after sustaining an undisclosed lower body injury during his club's 3-1 loss to the Los Angeles Kings on Saturday night.
Parise, who scored a team-leading 38 goals with the Devils last season, didn't play in the third period. The injury might have occurred when he was hit on the right knee during a hard check by Kyle Clifford midway through the second period.
His last shift ended with 1:43 remaining in the middle frame.
Parise, who averaged 36.5 goals over the previous four seasons, has three goals and two assists in 11 games. He scored 82 points in 81 games last season for the Devils.
It's the latest blow for New Jersey, last in the Eastern Conference with a 3-8-1 record.
Forward Brian Rolston and blue-liner Anton Volchenkov were injured in the first week of the season and have yet to return, while defencemen Bryce Salvador, Mark Fraser, Matt Corrente are also on the sidelines.
Volchenkov could return from a broken nose and stiff neck sometime in the coming week, with New Jersey continuing a six-game road trip Monday in Vancouver.
The Devils under first-year coach John MacLean have iced a roster with fewer than 18 skaters as a result of the injuries and salary cap issues.