Joe Pavelski and Logan Couture each scored twice to spoil Schneider's return to the nets for Vancouver and the San Jose Sharks won their third straight game to open the playoffs, beating the Canucks 5-2 on Sunday night.
Schneider was out the first two games of the series with an undisclosed injury.
Schneider made 33 saves and the Vancouver Canucks clinched a playoff berth with a 2-1 shootout victory over the Detroit Red Wings on Saturday night.
Schneider was 0-2-1 with a 3.24 goals-against average in his previous three games.
Schneider made 35 saves in regulation but surrendered two goals on three shootout chances in Tuesday's 2-1 loss to St. Louis.
Schneider has lost his last four road starts.
Schneider was supposed to start for Vancouver but fell ill so he missed out in Wednesday's 4-1 win over the hapless Flames.
Roberto Luongo, in a surprise start, made 40 saves as he replaced Schneider.
Schneider made 36 saves - many of the highlight-reel variety - as the Canucks beat the reeling Calgary Flames 5-2 on Saturday night to move four points ahead of the Minnesota Wild for first place in the Northwest Division.
Making his 10th straight start, eight of which have been victories, Schneider has grabbed the No. 1 role over Roberto Luongo the past three weeks.
Schneider made 17 saves and Max Lapierre scored the shootout-winning goal and the Canucks beat the Blue Jackets 1-0 on Tuesday for their fifth straight victory.
Schneider has a 0.99 GAA while winning each of his last five starts.
Schneider turned back 26 shots in a 3-2 victory over Colorado on Sunday night.
Schneider stayed hot, giving him a 4-0-0 record and a 1.25 goals-against average over his last four starts.
Schneider made 20 saves en route to his sixth NHL shutout, Mason Raymond scored in the first period, and the Canucks beat the Los Angeles Kings 1-0 on Saturday for their third straight victory.
Schneider has played the last three games for the Canucks, facing 88 shots and allowing only three goals. His other shutout this season was on Jan. 26, when he made 30 saves in a 5-0 victory at Anaheim.
Schneider stopped 33 shots and the Canucks grinded out a 2-1 win over the struggling Phoenix Coyotes on Thursday night.
Schneider won his first game in nearly three weeks against St. Louis on Tuesday and was sharp again, turning away some tough chances in the third period.
Schneider made 32 saves in Tuesday's win.
This snapped a personal three-game skid.