Ryan Nugent-Hopkins lasted just two games in his return to Edmonton's lineup, suffering a shoulder injury in Monday's loss to the Toronto Maple Leafs.
The Oilers said Tuesday that the talented rookie will miss seven to 10 days of action.
The latest injury occurred on a play involving Toronto grinder Mike Brown.
"We just both going for the puck and we just collided, shoulder to shoulder," Nugent-Hopkins told the team's website.
Nugent-Hopkins had just returned to the lineup on the weekend against Detroit.
He said he's trying to stay positive in light of the latest challenge this season, having suffered a shoulder injury in a Jan. 2 game against Chicago.
Nugent-Hopkins said it's the same shoulder, but a different injury.
The No. 1 overall draft pick from last June still leads all first year NHL players with 35 points (12G, 23A), although New Jersey's Adam Henrique is now just one point behind.
Edmonton next plays Wednesday in Detroit and then Thursday in Colorado.