LeSean McCoy ran 50 yards for the go-ahead score on a fourth-and-1 late in the fourth quarter, and the Philadelphia Eagles rallied to beat the New York Giants 27-17 after blowing a 13-point lead Sunday night.
Michael Vick looked a little more ordinary after a spectacular performance in a 59-28 win over Washington Monday night, but he led the Eagles (7-3) to a comeback win nonetheless, and helped give them sole possession of first place in the NFC East.
Eli Manning threw a pair of touchdown passes to bring New York (6-4) back from a 16-3 deficit. But he lost a fumble after running for a first down on fourth-and-6 with 2:51 left, and the Eagles recovered. Manning scrambled 16 yards and dove headfirst, but the ball came loose when he hit the ground untouched and Darryl Tapp recovered.
The Giants, who had a fumble overturned earlier in the quarter, lost this challenge.
McCoy took a pitch from Vick, who bobbled the snap, burst through a hole on the left side and sprinted into the end zone to put Philadelphia up 22-17. Vick connected with Jason Avant on the two-point conversion with 4:25 left.
Three plays before Manning's fumble, Asante Samuel made his second interception but fumbled on the return and the Giants recovered.
Tom Brady passing, Danny Woodhead running — and tackling. An unbeatable combination, even for Peyton Manning.
Brady was brilliant for the second straight week, outdueling Manning in their annual meeting to lead New England's victory over Indianapolis. Coming off a 350-yard, three-touchdown performance against Pittsburgh, Brady had only six incompletions in 25 passes and threw for two TDs.
Woodhead, picked up when the Jets cut him in September, scored on a weaving 36-yard burst, showing power, speed and agility. Seconds after his brilliant run, Woodhead made a sensational tackle on the ensuing kick return, drawing as many cheers as he did while scooting into the end zone.
Brady not only beat four-time MVP Manning, the only other quarterback of the last decade in his class, but tied another QB icon for an NFL mark. Brady has won 25 straight regular-season home starts, equalling Brett Favre's record when he was with Green Bay.
The win kept the Patriots (8-2) tied with the Jets atop the AFC East; they meet in two weeks.
Indianapolis (6-4), which has faced New England eight straight seasons, staged a spirited fourth-quarter comeback. But Manning was picked off by James Sanders in the final minute.
Indy had beaten the Patriots in five of the last six matchups. The Colts, who won their first 14 games a year ago en route to the AFC title, lead the AFC North. But they're so banged-up — they were without five key players Sunday — that considering them a Super Bowl contender right now might be a reach, even with Manning's magic.
Manning finished 38-of-52 for 396 yards, four TDs and three interceptions.
He got the Colts within 31-28 with 4:46 left on an 18-yard pass to Blair White, who earlier in the fourth period caught a five-yard TD toss. And Manning brought them within range of a stunning win before Sanders' pick.
Matt Ryan threw two touchdown passes and directed an offense so dominant that three St. Louis defenders left with cramps in the Atlanta Falcons' victory over the Rams.
Sam Bradford also had a pair of touchdown passes and set an NFL rookie record with 169 consecutive passes without an interception before William Moore picked off a shovel pass at the 2 with 3:24 to go. That was the clincher for the Falcons (8-2), who won their fourth in a row and ended the Rams' four-game home winning streak.
Ryan was 26 of 39 for 253 yards with touchdown passes to Brian Finneran and Justin Peelle, and Roddy White set up scores with nine catches for 83 yards.
The Rams fell to 4-6.
Drew Brees became the Saints' all-time completions leader, throwing for four touchdowns in New Orleans' win over the Seattle Seahawks.
Brees was 29-of-42 for 382 yards and completed his 1,850th pass as a Saint in the second quarter to break a record held by Archie Manning since 1982. Brees hit Marques Colston and Robert Meachem twice each for TDs to keep the defending champion Saints (7-3) one game behind NFC South Division leader Atlanta.
Matt Hasselbeck was 32-of-44 for 366 yards, the most yards allowed by New Orleans' top-ranked passing defence this season, but Seattle (5-5) had trouble getting in the end zone. The Seahawks lost two fumbles and had four drives end with field goals.
All it took for Tampa Bay to finally win again at Candlestick Park was a methodical, mistake-free day of football.
Josh Freeman threw for 136 yards and two touchdown passes and the Buccaneers beat the stagnant San Francisco 49ers for their first win in this stadium since 1980 and only second ever in 13 tries.
Nothing fancy needed for the Bucs (7-3) to end an eight-game losing streak in San Francisco. They were the underdog, no less.
Ronde Barber made his 40th career interception in the fourth quarter, most in Tampa Bay franchise history, to help clinch it. He also became the first player in NFL history to record 40 interceptions and 25 sacks in a career.
LeGarrette Blount ran for 82 yards and 305-pound left tackle Donald Penn made a late 1-yard touchdown catch.
Aaron Rodgers threw for 301 yards with three of his four touchdown passes to Greg Jennings, besting Brett Favre and Minnesota for the second time this season and sending the visiting Green Bay Packers to victory over the skidding Vikings.
The Packers (7-3) kept pace in the NFC North race with the Chicago Bears (7-3) and ruined any realistic hope the Vikings (3-7) had left to give Favre another shot at a playoff run in his 20th NFL season.
Instead, this 100th meeting between these border-state rivals, likely the last for the 41-year-old Favre, was marked by costly turnovers, untimely penalties and some sideline shouting by the frustrated Vikings.
Tramon Williams intercepted Favre to stop a long Vikings drive, and Rodgers took the Packers the other way for a touchdown to James Jones in the final minute of the first half to give the visitors a 17-3 lead.
Graham Gano kicked a 48-yard field goal with 8:17 left in overtime and the Washington Redskins beat the Tennessee Titans 19-16 after knocking Vince Young out of the game with an injured thumb on his throwing hand.
Washington (5-5) snapped a two-game skid and bounced back from a 59-28 loss to Philadelphia on Monday night. The win came on a day when at least seven Redskins went to the sideline with injuries, including Clinton Portis with a re-injured groin.
Gano's winner was his fourth field goal of the game. He also missed two — a 51-yarder to end the first half and a 47-yard attempt at the end of regulation that fell short.
With rookie Rusty Smith replacing Young, the Titans (5-5) lost their third straight game. Smith drove Tennessee to a field goal and a 16-13 lead in the fourth quarter. But they had to punt after winning the toss in overtime and never got the ball back.
Pittsburgh's James Harrison-led defence drove Jason Campbell from the game, caused two turnovers that Ben Roethlisberger turned into touchdown passes and the Steelers routed the Oakland Raiders 35-3.
Roethlisberger threw touchdown passes of 52 yards to Mike Wallace, 22 yards to rookie Emmanuel Sanders and 16 yards to Isaac Redman and scrambled 16 yards for a touchdown as the Steelers (7-3) bounced back in a big way after being rolled over by New England 39-26 at Heinz Field the week before.
Harrison, the former AP NFL Defensive Player of the Year, had five tackles, two sacks, an interception and a forced fumble, plus a penalty for slamming Campbell to the turf as the quarterback was throwing a pass.
Santonio Holmes caught a six-yard touchdown pass from Mark Sanchez with 10 seconds left, lifting the New York Jets to a stunning 30-27 comeback victory over the Houston Texans.
After New York blew a 16-point lead in the fourth quarter, the Jets trailed 27-23 with less than a minute left. But Sanchez completed two passes to LaDainian Tomlinson and then had a pretty 42-yard pass to Braylon Edwards with 16 seconds remaining.
On the next play, Sanchez found Holmes streaking into the left corner of the end zone for the winning score for the Jets (8-2). A video replay confirmed that Holmes, whose 37-yard touchdown catch won it in overtime at Cleveland last week, got both feet in bounds.
It was another heartbreaking loss for the Texans (4-6), who fell last week on a desperation heave
Dwayne Bowe caught two touchdown passes, giving him a team-record six straight games with at least one score, and Kansas City remained unbeaten at home with a 31-13 victory over the fading Arizona Cardinals.
In his last six games, Bowe has 563 yards receiving and 10 touchdown catches for the Chiefs (6-4), who started the day tied with Oakland in the AFC West. Thomas Jones also had two touchdowns for the Chiefs, who are 5-0 at home.
The fifth straight loss for the Cardinals (3-7) plunged the two-time defending NFC West champions 2 ½ games behind Seattle, which played later in New Orleans.
Maurice Jones-Drew followed a 75-yard reception with a one-yard touchdown dive, and the Jacksonville Jaguars overcame turnover problems to beat the banged-up Cleveland Browns 24-20.
Jones-Drew broke four tackles on a screen pass from David Garrard and weaved his way toward the end zone. Rookie Joe Haden made a touchdown-saving tackle that ended up taking precious seconds off the clock.
Jones-Drew scored two plays later, giving both teams dramatic finishes for the second time in as many games.
The Jaguars (6-4) beat Houston last week on Garrard's desperation pass to Mike Thomas on the final play. The Browns (3-7) lost to the New York Jets in overtime on Santonio Holmes' 37-yard TD reception.
Cleveland had a final chance to win this one, but Sean Considine tipped Colt McCoy's pass to Mike Bell at the goal-line. The pass bounced off Bell's chest and landed in Considine's arms.
Ryan Fitzpatrick matched his career high with four touchdown passes during Buffalo's biggest comeback in 13 years, and the Bills won their second straight game, 49-31 over the bumbling Cincinnati Bengals.
The Bengals (2-8) appeared to be in control after Johnathan Joseph's interception return put them ahead 28-7 in the second quarter. The Bengals' smallest crowd since 2003 saw a vintage collapse.
Buffalo (2-8) took advantage of Cincinnati's depleted secondary — Joseph and safety Chris Crocker went out late in the first half — for its biggest comeback since it overcame a 26-0 deficit and topped the Colts 37-35 on Sept. 21, 1997, according to STATS LLC.
Steve Johnson caught three of the touchdown passes, including an 11-yarder that put Buffalo ahead 35-31 early in the fourth quarter. Johnson finished with eight catches for 137 yards.
Bryan McCann grabbed a batted-down punt and returned it 97 yards for a touchdown, Miles Austin had two short touchdown catches and 38-year-old Jon Kitna had a career-best 29-yard touchdown run to lift the Dallas Cowboys to a 35-19 victory over the Detroit Lions.
Cowboys interim coach Jason Garrett won his home debut and improved to 2-0 since taking over for Wade Phillips. It's the first time this season Dallas (3-7) has won consecutive games and the first time all season it won at home, having lost the first four.
The Lions (2-8) lost their 26th straight on the road, extending a woeful NFL record that began in 2007, when Kitna was their quarterback.
Joe Flacco threw for 301 yards and a touchdown, Baltimore's defence returned consecutive interceptions for TDs in the fourth quarter, and the Ravens beat Brian St. Pierre and the Carolina Panthers 37-13.
The Ravens (7-3) recovered after a disheartening loss to Atlanta 10 days earlier by finally rattling Carolina's quarterback to break open a surprisingly close game. With Baltimore leading 23-13, Ed Reed picked off St. Pierre, then pitched it to Dawan Landry for a touchdown.
On the next play, St. Pierre was intercepted by Ray Lewis, who rumbled 24 yards for a score.
It wiped out a potential storybook performance by St. Pierre, signed by Carolina (1-9) a little over a week ago. He threw an 88-yard TD pass to David Gettis to get the Panthers within a touchdown.