Tampa Bay Buccaneers cornerback Ronde Barber, left, attempts to wrap up New England's Wes Welker. Tampa Bay Buccaneers cornerback Ronde Barber, left, attempts to wrap up New England's Wes Welker. (Stephan Savoia/Associated Press)

Tom Brady threw three touchdown passes and had more than 300 yards as the New England Patriots (5-2) beat the winless Tampa Bay Buccaneers 35-7 at Wembley Stadium on Sunday in the NFL's third regular-season game at the iconic London venue.

For the Bucs, who gave up a home game to play in London, the new surroundings didn't help. They fell to 0-7 and saw their losing streak extended to 11 games overall.

The Patriots were coming off a 59-0 win over the Tennessee Titans last week where Brady tossed six TD passes. New England wasn't as overpowering this time and Brady threw two interceptions in an uneven first-half performance.

Brady had TD passes to Wes Welker, Sam Aiken and Benjamin Watson. He finished 23-of-32 for 308 yards and was replaced late in the game by Brian Hoyer.

"I'm feeling great," Brady said. "I keep rolling. That's two wins in a row. We went out there and put two touchdowns on the board there in the second half. We had plenty of distractions coming over here, but everybody was really energized. To get the win and fly home and have a [bye] week off is just great."

Tampa Bay and quarterback Josh Johnson mustered little offence. The Bucs' only score came on a 33-yard pass from Johnson to Antonio Bryant near the end of the first half. Johnson finished 9-of-26 for 156 yards and three interceptions. He was taken out midway through the fourth quarter and replaced by rookie Josh Freeman.

Perfect Saints rally past Dolphins

The unbeaten Saints overcame an early 21-point deficit, mounting touchdown drives of 82, 79 and 60 yards on successive possessions in the second half to overtake the Dolphins 46-34.

NFL passing leader Drew Brees had his worst day of the season, with three interceptions and five sacks. But he scored twice, the second time on a two-yard keeper with 8:35 left to give the Saints their first lead.

Tracy Porter's 54-yard interception return sealed the win for the Saints (6-0), off to their best start since 1991. The league's highest-scoring team topped 40 points for the fourth time.

Steelers' D hands Vikings 1st loss

LaMarr Woodley returned Brett Favre's fumble 77 yards for a touchdown and Keyaron Fox ran back an interception 82 yards for another score during the closing minutes in a 27-17 Pittsburgh Steelers' home victory that handed the Minnesota Vikings their first loss.

Two goal-line stands helped turned the anticipated quarterback showdown between Favre and Ben Roethlisberger into a defensive duel. And the Super Bowl champion Steelers (5-2) are tough to beat in any game that's decided by defence.

The Vikings (6-1) had a first down inside the Steelers' one-yard line during the third quarter but settled for a field goal.

Cardinals beat turnover-prone Giants

The Arizona Cardinals bewildered New York quarterback Eli Manning with their blitzes, forced four turnovers and used timely plays by their veterans to beat the hometown Giants 24-17.

Kurt Warner, who was 6-2 as a starter with the Giants in 2004, threw for one touchdown and got plenty of help from star receiver Larry Fitzgerald and a staunch defence led by safety Adrian Wilson.

With less-heralded Cardinals Jason Wright, Tim Hightower and rookie Beanie Wells finding the end zone, Arizona (4-2) took over first place in the NFC West. The Giants (5-2) lost their second in a row.

Romo returns to form in Cowboys' win

Tony Romo returned to his swashbuckling style, keeping drives alive by improvising and turning one near-disaster into a touchdown, and Miles Austin proved his breakout game was no fluke by coming up with big plays for Dallas in a 37-21 home win over Atlanta.

With Romo and Austin bringing the offence to life and the defence giving up little more than long drives at the start of each half, the Cowboys (4-2) roared out of their bye with their most impressive win of the season and first against a team with a winning record.

The Falcons (4-2) came in looking to keep pace with the best start in franchise history. Matt Ryan started great, but couldn't keep it up. His streak of 142 passes without a sack ended with takedowns on consecutive plays in the first quarter. He was sacked four times, threw two interceptions and lost a fumble.

Rookie Byrd keys Bills' victory

Jairus Byrd had two more interceptions, Ryan Fitzpatrick didn't make a big mistake in his first start at quarterback and the Bills took advantage of Carolina's miscues for a 20-9 road win.

Buffalo won despite being outgained 425-167. Carolina led in first downs 20-9 and held the ball for nearly 35 minutes. But Jake Delhomme was intercepted three times, Kenny Moore fumbled a punt, John Kasay missed two field goal attempts and the Panthers (2-4) saw their two-game winning streak snapped.

Byrd, a rookie, had two interceptions to set up touchdowns as Buffalo (3-3) won road games in consecutive weeks for the first time since 2004.

Colts destroy hapless Rams

Peyton Manning threw for three touchdowns but didn't get a chance for a sixth straight 300-yard passing game in the visiting Indianapolis Colts' 42-6 rout of the winless St. Louis Rams.

It wouldn't have been appropriate for Manning to try to tie the NFL record the way his unbeaten team was beating up on the woeful Rams (0-7). He was 23-for-34 for 235 yards.

The Colts defence got its first score of the year on rookie Jacob Lacey's 35-yard interception return. Looking fresh coming off their bye, the Colts (6-0) won their 15th straight regular-season game and set a franchise record with their eighth straight road victory.

Packers prep for Favre by routing Browns

Aaron Rodgers threw three touchdown passes, Ryan Grant rushed for 148 yards and the visiting Green Bay Packers warmed up for Brett Favre's first visit back to Lambeau Field next week with a 31-3 laugher against the Cleveland Browns, who are over the flu but can't shake other problems.

It would have been understandable if the visiting Packers (4-2) had overlooked an inferior opponent with their eyes on Favre's hyped return to Wisconsin with the Minnesota Vikings.

But Rodgers and his teammates took care of business against the Browns (1-6), who have scored just four offensive touchdowns and 72 points all season. The flu ran through the Cleveland locker room in the week leading up to the game and a few starters missed practice time because of it.

Palmer, Benson pummel Bears

Carson Palmer threw five touchdown passes — four of them in a dominant first half — and Cedric Benson ran for a career-high 189 yards and a touchdown against the team that let him go as Cincinnati beat up on visiting Chicago 45-10.

The Bengals improved to 5-2 for the first time since 2005, when a fast-strike offence got them to the playoffs. There was a strong resemblance in the first half, when Cincinnati scored on all five possessions and went up 31-0. That tied the third-most points the Bears (3-3) have allowed in an opening half.

Jets blank Raiders

Mark Sanchez shook off the worst start of his young career by running for one touchdown and throwing for another, fellow rookie Shonn Greene ran for 144 yards and two scores and the Jets snapped a three-game losing streak with a 38-0 victory in Oakland.

It was a low-pressure day for Sanchez, who started two of his first three drives for the Jets (4-3) at the Oakland four after turnovers by JaMarcus Russell. Those mistakes led to touchdown runs by Thomas Jones and Sanchez, and played a role in Oakland coach Tom Cable's decision to bench the former No. 1 overall pick in the second quarter.

This was just the fifth home shutout ever for the Raiders (2-5), with four coming in the past four seasons.

Rivers, Chargers bury Chiefs

Philip Rivers threw three touchdowns passes and LaDainian Tomlinson rushed for 71 yards as the San Diego Chargers defeated the hometown Kansas City Chiefs 37-7.

Rivers was 18-for-30 for 268 yards and three TDs as the Chargers won their third in a row in Kansas City for the first time since 1981.

The Chiefs (1-6) had hoped a sloppy win over Washington the week before might provide some much-needed momentum. But they played miserably in just about every phase of the game, falling behind 20-0 in the first half.

Matt Cassel threw three interceptions and the Chargers (3-3) scored their final touchdown when Jacob Hester blocked a punt at the 20, chased the ball into the end zone and fell on it.

Texans hold on to edge 49ers

Steve Slaton scored two touchdowns and the hometown Houston Texans built a big lead then held on to beat San Francisco 24-21.

The Texans led 21-0 at halftime then withstood a rally led by backup quarterback Alex Smith. Eugene Wilson's interception on fourth down halted a last-gasp drive by the 49ers (3-3).

San Francisco benched Shaun Hill after a terrible first half and Smith threw three touchdowns to Vernon Davis to close the gap. Michael Crabtree started in his NFL debut and had five receptions for 56 yards.

The Texans (4-3) won consecutive games for the first time this season.