New York Jets receiver Santonio Holmes had to be helped from the field after hurting his left leg on the first play of the fourth quarter against San Francisco.
Holmes went down after catching a short pass, which he fumbled, with Carlos Rogers returning it 51 yards for a touchdown. Trainers helped him off and he was not putting any weight on the leg, then Holmes was carted to the locker room.
Earlier Sunday, the Jets lost tight end Dedrick Epps to a right knee injury and fullback John Conner to a hamstring problem.
Tennessee quarterback Jake Locker injured his left shoulder after being sacked by the Houston Texans in the first quarter.
He returned to the sideline in the second quarter in street clothes with his left arm in a sling.
Locker was sacked by Glover Quin and thrown to the ground. He remained there for a few minutes in pain while trainers attended to him. He eventually got up and walked off the field before being taken to the locker room.
Matt Hasselbeck came in for Locker on the next series.
Locker injured the same shoulder in Tennessee's season-opening loss against New England.