| Time Remaining | Down | Team | Details |
|---|---|---|---|
| 15:00 | BUF | John Potter kicks off to the SF0. Kyle Williams return for 17 yards to SF14. Tackled by Chris White. | |
| 14:53 | 1st and 10 @ SF14 | SF | Frank Gore rush to the left for 5 yards to the SF19. Tackled by George Wilson. |
| 14:18 | 2nd and 5 @ SF19 | SF | Alex Smith pass to the right to Michael Crabtree for 4 yards to the SF23. Tackled by Kelvin Sheppard. |
| 13:41 | 3rd and 1 @ SF23 | SF | Penalty: Holding on San Francisco (Mike Iupati) -10 yards. |
| 13:10 | 3rd and 11 @ SF13 | SF | Alex Smith pass to the right to Mario Manningham for 9 yards to the SF22. Tackled by Aaron Williams. |
| 12:31 | 4th and 2 @ SF22 | SF | Andy Lee punts for 58 yards to Buf20. Leodis McKelvin return for 28 yards to Buf48. Penalty: Holding on Buffalo (Jairus Byrd) -10 yards. |
| 12:15 | 1st and 10 @ Buf38 | BUF | Fred Jackson rush to the right for 4 yards to the Buf42. Tackled by Justin Smith. |
| 11:33 | 2nd and 6 @ Buf42 | BUF | Fred Jackson rush to the left for a loss of 1 yard to the Buf41. Tackled by Ahmad Brooks. |
| 10:56 | 3rd and 7 @ Buf41 | BUF | Ryan Fitzpatrick incomplete pass to the right intended for Stevie Johnson. |
| 10:49 | 4th and 7 @ Buf41 | BUF | Shawn Powell punts for 59 yards to SF0. Touchback. |
| 10:42 | 1st and 10 @ SF20 | SF | Frank Gore rush up the middle for 19 yards to the SF39. Tackled by Stephon Gilmore. |
| 10:02 | 1st and 10 @ SF39 | SF | Alex Smith pass to the right to Vernon Davis for 53 yards to the Buf8. Tackled by Aaron Williams. |
| 9:28 | 1st and 8 @ Buf8 | SF | Frank Gore rush up the middle for 7 yards to the Buf1. Tackled by Kyle Williams. |
| 8:52 | 2nd and 1 @ Buf1 | SF | Frank Gore rush up the middle for no gain to the Buf1. Tackled by Nick Barnett. |
| 8:14 | 3rd and 1 @ Buf1 | SF | Frank Gore rush to the left for no gain to the Buf1. Tackled by Nick Barnett. |
| 7:29 | 4th and 1 @ Buf1 | SF | David Akers 19 yard field goal attempt is GOOD. Holder: Andy Lee. |
| 7:25 | SF | David Akers kicks off to the Buf0. Leodis McKelvin return for 59 yards to SF44. Tackled by Tramaine Brock. | |
| 7:14 | 1st and 10 @ SF44 | BUF | Ryan Fitzpatrick pass to the left to Stevie Johnson for 7 yards to the SF37. |
| 6:46 | 2nd and 3 @ SF37 | BUF | Fred Jackson rush to the right for 4 yards to the SF33. Tackled by Justin Smith. |
| 6:01 | 1st and 10 @ SF33 | BUF | Ryan Fitzpatrick incomplete pass to the right intended for Stevie Johnson. |
| 5:56 | 2nd and 10 @ SF33 | BUF | C.J. Spiller rush to the left for a loss of 5 yards to the SF38. Tackled by NaVorro Bowman. |
| 5:14 | 3rd and 15 @ SF38 | BUF | Ryan Fitzpatrick pass to the middle to Brad Smith for 1 yard to the SF37. Tackled by Patrick Willis. |
| 4:37 | 4th and 14 @ SF37 | BUF | Shawn Powell punts for 24 yards to SF13. No return. |
| 4:29 | 1st and 10 @ SF13 | SF | Alex Smith pass to the left to Michael Crabtree for 19 yards to the SF32. Tackled by Kelvin Sheppard. |
| 3:45 | 1st and 10 @ SF32 | SF | Penalty: False Start on San Francisco (Joe Staley) -5 yards. |
| 3:24 | 1st and 15 @ SF27 | SF | Kyle Williams rush to the left for 6 yards to the SF33. Tackled by Arthur Moats. |
| 2:58 | 2nd and 9 @ SF33 | SF | Penalty: Illegal Block on San Francisco (Frank Gore) -15 yards. |
| 2:27 | 2nd and 24 @ SF18 | SF | Alex Smith incomplete pass to the left intended for Kendall Hunter. |
| 2:23 | 3rd and 24 @ SF18 | SF | Alex Smith pass to the left to Michael Crabtree for 16 yards to the SF34. Tackled by Bryan Scott and Aaron Williams. |
| 1:40 | 4th and 8 @ SF34 | SF | Andy Lee punts for 54 yards to Buf12. No return. |
| 1:30 | 1st and 10 @ Buf12 | BUF | C.J. Spiller rush up the middle for 4 yards to the Buf16. Tackled by NaVorro Bowman. |
| 0:50 | 2nd and 6 @ Buf16 | BUF | Ryan Fitzpatrick pass to the left to Donald Jones for 8 yards to the Buf24. Tackled by Carlos Rogers and NaVorro Bowman. |
| 0:03 | 1st and 10 @ Buf24 | BUF | Ryan Fitzpatrick pass to the left to Stevie Johnson for 14 yards to the Buf38. Tackled by Tarell Brown. |
| Time Remaining | Down | Team | Details |
|---|---|---|---|
| 15:00 | 1st and 10 @ Buf38 | BUF | C.J. Spiller rush up the middle for 2 yards to the Buf40. Tackled by NaVorro Bowman. |
| 14:24 | 2nd and 8 @ Buf40 | BUF | Ryan Fitzpatrick pass to the left to Scott Chandler for 3 yards to the Buf43. Tackled by Patrick Willis. |
| 13:41 | 3rd and 5 @ Buf43 | BUF | Ryan Fitzpatrick pass to the right to T.J. Graham for 9 yards to the SF48. Tackled by Dashon Goldson and Chris Culliver. |
| 13:01 | 1st and 10 @ SF48 | BUF | Ryan Fitzpatrick pass to the right to Scott Chandler for 20 yards to the SF28. Tackled by Donte Whitner. |
| 12:18 | 1st and 10 @ SF28 | BUF | C.J. Spiller rush to the right for 12 yards to the SF16. Tackled by Donte Whitner. |
| 11:41 | 1st and 10 @ SF16 | BUF | Ryan Fitzpatrick incomplete pass to the right intended for Stevie Johnson. |
| 11:36 | 2nd and 10 @ SF16 | BUF | Ryan Fitzpatrick pass to the left to Stevie Johnson for 8 yards to the SF8. Tackled by Tarell Brown and Carlos Rogers. |
| 10:54 | 3rd and 2 @ SF8 | BUF | Ryan Fitzpatrick incomplete pass to the middle intended for Donald Jones. |
| 10:50 | 4th and 2 @ SF8 | BUF | Penalty: False Start on Buffalo (Alex Carrington) -5 yards. |
| 10:50 | 4th and 7 @ SF13 | BUF | Rian Lindell 31 yard field goal attempt is GOOD. Holder: Shawn Powell. |
| 10:46 | BUF | John Potter kicks off to the SF0. Kyle Williams return for 28 yards to SF26. Tackled by Brad Smith. | |
| 10:40 | 1st and 10 @ SF26 | SF | Penalty: False Start on San Francisco (Mike Iupati) -5 yards. |
| 10:40 | 1st and 15 @ SF21 | SF | Alex Smith pass to the middle to Michael Crabtree for 36 yards to the Buf43. Tackled by Stephon Gilmore. |
| 10:02 | 1st and 10 @ Buf43 | SF | Alex Smith pass to the right to Kyle Williams for 43 yards for a TOUCHDOWN. |
| 9:54 | SF | David Akers extra point is good. | |
| 9:54 | SF | David Akers kicks off to the Buf0. Touchback. | |
| 9:54 | 1st and 10 @ Buf20 | BUF | C.J. Spiller rush to the right for 3 yards to the Buf23. Tackled by Patrick Willis. |
| 9:13 | 2nd and 7 @ Buf23 | BUF | Ryan Fitzpatrick pass to the right to Stevie Johnson for 8 yards to the Buf31. Tackled by Chris Culliver. |
| 8:32 | 1st and 10 @ Buf31 | BUF | C.J. Spiller rush to the left for 5 yards to the Buf36. Tackled by Justin Smith. |
| 7:54 | 2nd and 5 @ Buf36 | BUF | C.J. Spiller rush to the left for 3 yards to the Buf39. Tackled by Dashon Goldson. |
| 7:13 | 3rd and 2 @ Buf39 | BUF | Ryan Fitzpatrick incomplete pass to the left intended for C.J. Spiller. |
| 7:08 | 4th and 2 @ Buf39 | BUF | Shawn Powell punts for 58 yards to SF3. No return. |
| 6:59 | 1st and 10 @ SF3 | SF | Frank Gore rush up the middle for 1 yard to the SF4. Tackled by Mario Williams. |
| 6:21 | 2nd and 9 @ SF4 | SF | Frank Gore rush to the left for 2 yards to the SF6. Tackled by Nick Barnett. |
| 5:39 | 3rd and 7 @ SF6 | SF | Penalty: Tripping on San Francisco (Delanie Walker) -3 yards. |
| 5:13 | 3rd and 10 @ SF3 | SF | Kendall Hunter rush up the middle for 12 yards to the SF15. Tackled by Jairus Byrd and Aaron Williams. |
| 4:32 | 1st and 10 @ SF15 | SF | Kendall Hunter rush to the left for 1 yard to the SF16. Tackled by Mark Anderson. |
| 3:52 | 2nd and 9 @ SF16 | SF | Alex Smith pass to the left to Mario Manningham for no gain to the SF16. Tackled by George Wilson. |
| 3:10 | 3rd and 9 @ SF16 | SF | Alex Smith rush up the middle for 24 yards to the SF40. |
| 2:26 | 1st and 10 @ SF40 | SF | Penalty: Offside on Buffalo (Kyle Williams) 5 yards. |
| 2:05 | 1st and 5 @ SF45 | SF | Alex Smith incomplete pass to the middle intended for Michael Crabtree defensed by Stephon Gilmore. |
| 2:00 | 2nd and 5 @ SF45 | SF | Two Minute Warning. |
| 2:00 | 2nd and 5 @ SF45 | SF | Alex Smith pass to the right to Vernon Davis for 17 yards to the Buf38. Tackled by Stephon Gilmore. |
| 1:31 | 1st and 10 @ Buf38 | SF | Alex Smith pass to the right to Vernon Davis for 1 yard to the Buf37. Tackled by Nigel Bradham. |
| 1:26 | 2nd and 9 @ Buf37 | SF | San Francisco 49ers timeout. |
| 1:26 | 2nd and 9 @ Buf37 | SF | Alex Smith pass to the middle to Vernon Davis for 11 yards to the Buf26. Tackled by Justin Rogers. |
| 0:58 | 1st and 10 @ Buf26 | SF | Alex Smith incomplete pass to the left intended for Vernon Davis. |
| 0:58 | 2nd and 10 @ Buf26 | SF | Colin Kaepernick rush to the left for 6 yards to the Buf20. Tackled by Nick Barnett. FUMBLE, recovered by Buf (Marcell Dareus). Tackled by Delanie Walker. |
| 0:49 | 1st and 10 @ Buf17 | BUF | Ryan Fitzpatrick incomplete pass to the left intended for T.J. Graham. |
| 0:40 | 2nd and 10 @ Buf17 | BUF | Fred Jackson rush to the left for 4 yards to the Buf21. Tackled by Patrick Willis. |
| 0:37 | 3rd and 7 @ Buf21 | BUF | San Francisco 49ers timeout. |
| 0:37 | 3rd and 6 @ Buf21 | BUF | Ryan Fitzpatrick pass to the middle to Scott Chandler for 11 yards to the Buf32. Tackled by Patrick Willis. FUMBLE, recovered by SF (Dashon Goldson) and returned for 5 yards. Tackled by Fred Jackson. |
| 0:29 | 1st and 10 @ Buf28 | SF | Alex Smith pass to the left to Michael Crabtree for 28 yards for a TOUCHDOWN. |
| 0:24 | SF | David Akers extra point is good. | |
| 0:24 | SF | David Akers kicks off to the Buf0. Touchback. | |
| 0:24 | 1st and 10 @ Buf20 | BUF | Ryan Fitzpatrick rush up the middle for a loss of 1 yard to the Buf19. |
| Time Remaining | Down | Team | Details |
|---|---|---|---|
| 15:00 | SF | David Akers kicks off to the Buf0. Touchback. | |
| 15:00 | 1st and 10 @ Buf20 | BUF | Fred Jackson rush to the right for 7 yards to the Buf27. Tackled by Justin Smith. |
| 14:23 | 2nd and 3 @ Buf27 | BUF | Fred Jackson rush up the middle for 4 yards to the Buf31. Tackled by Carlos Rogers. |
| 13:45 | 1st and 10 @ Buf31 | BUF | Ryan Fitzpatrick sacked at Buf20 for a loss of 11 yards by Ahmad Brooks. |
| 13:08 | 2nd and 21 @ Buf20 | BUF | Ryan Fitzpatrick rush to the right for 2 yards to the Buf22. Tackled by Patrick Willis. |
| 12:28 | 3rd and 19 @ Buf22 | BUF | Ryan Fitzpatrick pass to the right to Fred Jackson for 5 yards to the Buf27. Tackled by Perrish Cox. |
| 12:01 | 4th and 14 @ Buf27 | BUF | Shawn Powell punts for 39 yards to SF34. Ted Ginn Jr. - no return. Tackled by Garrison Sanborn. |
| 11:50 | 1st and 10 @ SF34 | SF | Penalty: False Start on San Francisco (Frank Gore) -5 yards. |
| 11:50 | 1st and 15 @ SF29 | SF | Alex Smith pass to the right to Vernon Davis for 24 yards to the Buf47. Tackled by Arthur Moats. |
| 11:22 | 1st and 10 @ Buf47 | SF | Penalty: Holding on San Francisco (Joe Staley) -10 yards. |
| 11:14 | 1st and 20 @ SF43 | SF | Alex Smith pass to the right to Michael Crabtree for 10 yards to the Buf47. Tackled by Jairus Byrd and Aaron Williams. |
| 10:35 | 2nd and 10 @ Buf47 | SF | Frank Gore rush to the left for 31 yards to the Buf16. Tackled by Marcell Dareus. |
| 10:01 | 1st and 10 @ Buf16 | SF | Colin Kaepernick rush to the left for 15 yards to the Buf1. Tackled by Stephon Gilmore and Jairus Byrd. |
| 10:01 | 1st and 1 @ Buf1 | SF | Frank Gore rush up the middle for 1 yard for a TOUCHDOWN. |
| 9:06 | SF | David Akers extra point is good. | |
| 9:06 | SF | David Akers kicks off to the Buf0. Touchback. | |
| 9:06 | 1st and 10 @ Buf20 | BUF | Ryan Fitzpatrick pass to the right to Scott Chandler for 6 yards to the Buf26. Tackled by Patrick Willis. |
| 8:27 | 2nd and 4 @ Buf26 | BUF | Ryan Fitzpatrick incomplete pass to the right intended for Scott Chandler. |
| 8:22 | 3rd and 4 @ Buf26 | BUF | Ryan Fitzpatrick pass to the left to T.J. Graham for 19 yards to the Buf45. Tackled by Donte Whitner. |
| 7:52 | 1st and 10 @ Buf45 | BUF | Brad Smith rush to the left for 35 yards to the SF20. Tackled by Dashon Goldson. |
| 7:10 | 1st and 10 @ SF20 | BUF | Ryan Fitzpatrick pass intended for Donald Jones INTERCEPTED by Chris Culliver and returned for 4 yards. Tackled by Donald Jones. |
| 7:00 | 1st and 10 @ SF6 | SF | Frank Gore rush up the middle for 2 yards to the SF8. Tackled by Nigel Bradham. |
| 6:22 | 2nd and 8 @ SF8 | SF | Kendall Hunter rush to the left for 3 yards to the SF11. Tackled by Mark Anderson. |
| 5:43 | 3rd and 5 @ SF11 | SF | Kendall Hunter rush to the left for 6 yards to the SF17. Tackled by Marcell Dareus. |
| 4:58 | 1st and 10 @ SF17 | SF | Penalty: Encroachment on Buffalo (Chris Kelsay) 5 yards. |
| 4:40 | 1st and 5 @ SF22 | SF | Bruce Miller rush to the left for 9 yards to the SF31. Tackled by Nigel Bradham. |
| 3:57 | 1st and 10 @ SF31 | SF | Alex Smith pass to the right to Mario Manningham for 7 yards to the SF38. Tackled by Da'Norris Searcy. |
| 3:27 | 2nd and 3 @ SF38 | SF | Frank Gore rush to the left for 17 yards to the Buf45. Tackled by Da'Norris Searcy. |
| 2:43 | 1st and 10 @ Buf45 | SF | Alex Smith pass to the right to Randy Moss for 11 yards to the Buf34. Tackled by George Wilson. |
| 2:02 | 1st and 10 @ Buf34 | SF | Alex Smith incomplete pass to the left intended for Mario Manningham. |
| 1:58 | 2nd and 10 @ Buf34 | SF | Anthony Dixon rush to the left for 9 yards to the Buf25. Tackled by George Wilson. |
| 1:16 | 3rd and 1 @ Buf25 | SF | San Francisco 49ers timeout. |
| 1:14 | 3rd and 1 @ Buf25 | SF | Frank Gore rush up the middle for 4 yards to the Buf21. Tackled by Stephon Gilmore. |
| 0:34 | 1st and 10 @ Buf21 | SF | Alex Smith pass to the right to Garrett Celek for 4 yards to the Buf17. Tackled by Nigel Bradham. |
| Time Remaining | Down | Team | Details |
|---|---|---|---|
| 15:00 | 2nd and 6 @ Buf17 | SF | Frank Gore rush up the middle for 7 yards to the Buf10. Tackled by Kyle Williams. |
| 14:16 | 1st and 10 @ Buf10 | SF | Alex Smith pass to the right to Mario Manningham for 10 yards for a TOUCHDOWN. |
| 14:12 | SF | David Akers extra point is good. | |
| 14:12 | SF | David Akers kicks off to the Buf0. Touchback. | |
| 14:12 | 1st and 10 @ Buf20 | BUF | Ryan Fitzpatrick pass to the left to Stevie Johnson for 2 yards to the Buf22. Tackled by Aldon Smith. |
| 13:31 | 2nd and 8 @ Buf22 | BUF | Ryan Fitzpatrick incomplete pass to the right intended for Scott Chandler defensed by NaVorro Bowman. |
| 13:26 | 3rd and 8 @ Buf22 | BUF | Ryan Fitzpatrick incomplete pass to the left intended for Stevie Johnson. |
| 13:22 | 4th and 8 @ Buf22 | BUF | Shawn Powell punts for 62 yards to SF16. Ted Ginn Jr. return for 10 yards to SF26. Tackled by Garrison Sanborn. |
| 13:09 | 4th and 8 @ Buf22 | BUF | Shawn Powell punts for 56 yards to SF22. Ted Ginn Jr. return for 11 yards to SF33. Tackled by Da'Norris Searcy. |
| 13:00 | 1st and 10 @ SF33 | SF | Frank Gore rush up the middle for 10 yards to the SF43. Tackled by George Wilson. |
| 12:15 | 1st and 10 @ SF43 | SF | Kendall Hunter rush to the left for 11 yards to the Buf46. Tackled by Nigel Bradham. |
| 11:32 | 1st and 10 @ Buf46 | SF | Alex Smith incomplete pass to the right intended for Randy Moss. |
| 11:26 | 2nd and 10 @ Buf46 | SF | Alex Smith incomplete pass to the right intended for Vernon Davis. |
| 11:21 | 3rd and 10 @ Buf46 | SF | Alex Smith rush up the middle for 8 yards to the Buf38. Tackled by Alex Carrington. |
| 10:50 | 4th and 2 @ Buf38 | SF | Alex Smith rush to the left for 17 yards to the Buf21. |
| 10:00 | 1st and 10 @ Buf21 | SF | San Francisco 49ers timeout. Penalty: Offside on Buffalo (Mark Anderson) 5 yards. |
| 10:00 | 1st and 5 @ Buf16 | SF | Colin Kaepernick rush to the left for 16 yards for a TOUCHDOWN. |
| 9:55 | SF | David Akers extra point is good. | |
| 9:55 | SF | David Akers kicks off to the Buf0. Touchback. | |
| 9:52 | 1st and 10 @ Buf20 | BUF | Fred Jackson rush to the right for 2 yards to the Buf22. Tackled by C.J. Spillman. |
| 9:14 | 2nd and 8 @ Buf22 | BUF | Ryan Fitzpatrick pass to the left to Stevie Johnson for no gain to the Buf22. Tackled by Tramaine Brock. |
| 8:31 | 3rd and 8 @ Buf22 | BUF | Ryan Fitzpatrick pass to the middle to Donald Jones for 5 yards to the Buf27. Tackled by Darcel McBath. |
| 7:52 | 4th and 3 @ Buf27 | BUF | Shawn Powell punts for 50 yards to SF23. Ted Ginn Jr. return for 8 yards to SF31. Tackled by Brad Smith. |
| 7:40 | 1st and 10 @ SF31 | SF | Kendall Hunter rush up the middle for 5 yards to the SF36. Tackled by Kyle Williams. |
| 7:00 | 2nd and 5 @ SF36 | SF | Colin Kaepernick rush to the right for 2 yards to the SF38. Tackled by Bryan Scott. |
| 6:30 | 3rd and 3 @ SF38 | SF | Colin Kaepernick pass to the right to Kyle Williams for 7 yards to the SF45. Tackled by Terrence McGee. |
| 5:48 | 1st and 10 @ SF45 | SF | Kendall Hunter rush to the right for 6 yards to the Buf49. Tackled by Nigel Bradham. |
| 5:03 | 2nd and 4 @ Buf49 | SF | Kendall Hunter rush to the left for 26 yards to the Buf23. Tackled by Da'Norris Searcy. |
| 4:14 | 1st and 10 @ Buf23 | SF | Kendall Hunter rush up the middle for 3 yards to the Buf20. Tackled by Mario Williams. |
| 3:32 | 2nd and 7 @ Buf20 | SF | Kendall Hunter rush to the right for 5 yards to the Buf15. Tackled by George Wilson. |
| 2:54 | 3rd and 2 @ Buf15 | SF | Kendall Hunter rush up the middle for 3 yards to the Buf12. Tackled by Mark Anderson. |
| 2:24 | 1st and 10 @ Buf12 | SF | Anthony Dixon rush to the right for 5 yards to the Buf7. Tackled by Bryan Scott. |
| 2:00 | 2nd and 5 @ Buf7 | SF | Two Minute Warning. |
| 2:00 | 2nd and 5 @ Buf7 | SF | Anthony Dixon rush up the middle for 4 yards to the Buf3. Tackled by Chris Kelsay. |
| 1:17 | 3rd and 1 @ Buf3 | SF | Anthony Dixon rush to the right for 3 yards for a TOUCHDOWN. |
| 1:11 | SF | David Akers extra point is good. | |
| 1:11 | SF | David Akers kicks off to the Buf10. Brad Smith return for 28 yards to Buf38. Tackled by Anthony Dixon. | |
| 1:03 | 1st and 10 @ Buf38 | BUF | Fred Jackson rush to the left for 4 yards to the Buf42. Tackled by Ricky Jean Francois. |
| 0:26 | 2nd and 6 @ Buf42 | BUF | Fred Jackson rush to the left for 1 yard to the Buf43. Tackled by Larry Grant and Demarcus Dobbs. |