As if a deflating season-opening loss wasn't bad enough in putting a dent in the Buffalo Bills' high expectations. Now they have injuries to two key offensive players to contend with.

Receiver David Nelson will miss the rest of the season after tearing a ligament in his right knee. The news is at least a little more encouraging for running back Fred Jackson, who will miss at least three weeks after he also hurt his right knee.

Coach Chan Gailey provided the update Monday afternoon, a day after both players were hurt in a dreadful 48-28 loss at the New York Jets.

"It's a setback," Gailey said. "You lose experience and you lose versatility. But I think our guys can adjust."

The injuries hit two key players on an offence that's already off to an inconsistent start after producing four turnovers against the Jets, including three interceptions by starter Ryan Fitzpatrick.

Buffalo attempts to regroup in preparing to face the Kansas City Chiefs (0-1) in its home opener Sunday.

Nelson has been a reliable target in the slot, and finished second on the team with 61 catches for 658 yards and five touchdowns last season.

Falcons lose franchise player Grimes

The Atlanta Falcons lost franchise player Brett Grimes to a torn Achilles tendon in their season-opening victory at Kansas City.

The cornerback got the franchise tag when he couldn't agree on a new contract, receiving a salary of $10.2 million. The Falcons also traded for Asante Samuel to boost their secondary, but now will be without Grimes for the rest of the season.

Rams down 2 offensive linemen

Rams offensive tackle Rodger Saffold has returned to St. Louis after spending the night in Detroit with a neck injury sustained against the Lions that coach Jeff Fisher called a "significant strain."

Saffold was discharged Sunday night from a hospital after results of several medical tests were negative He had a CT scan and X-rays.

Fisher declined to speculate on a time frame for Saffold's return, saying the player's status would be addressed on the injury report later in the week.

"We still have some further tests to do, but it appears at this point it's just a significant strain," Fisher said. "So he's very lucky. So that's good news on our behalf."

The Rams lost another offensive lineman, centre Scott Wells, in their opening loss. Wells broke the fifth metatarsal bone on his left foot and will need surgery.

Fisher said the Rams would use the new "marquee" injured reserve rule that allows them to activate one player off IR for Week 9, and bring back Wells then.

Wells, who got a four-year, $24 million US free agent deal from the Rams after a tenure with Green Bay that included a Super Bowl, has barely been on the field. He missed the first two preseason games coming off surgery on his right knee.

Saffold crumpled awkwardly after disengaging from Lions safety John Wendling when Brandon Gibson made a touchdown reception to give the Rams a 20-13 lead with 9:45 to go Sunday. After being carted off the field, he had movement in his arms and legs.

The 6-foot-5, 314-pound Saffold is in his third season with the Rams after getting drafted in the second round in 2010. He started nine games last season, but missed the last seven games with a pectoral injury.

Darrelle Revis sustains 'mild concussion'

Jets cornerback Darrelle Revis has what the team calls a "mild concussion," and his status for New York's game at Pittsburgh next Sunday was uncertain.

Coach Rex Ryan says Monday that Revis "seems to be feeling good," but adds that the team will always err on the side of caution with head injuries.

Revis was injured midway through the fourth quarter of the Jets' 48-28 victory over the Buffalo Bills when he dived to tackle C.J. Spiller and was then accidentally kicked in the head by teammate Bart Scott. Revis stayed down or a few moments as trainers ran out to tend to him.

He remained on the sideline for a few moments with his helmet on as trainers talked with him before eventually heading into the locker room.

Redskins' long snapper plays with broken arm

It'll go down as the other remarkable performance in Robert Griffin III's stellar NFL debut: Washington's long snapper was playing with a broken arm.

Nick Sundberg broke his left arm in the first half of the Redskins' 40-32 win over the New Orleans Saints on Sunday.

But Sundberg continued to play. He snapped the ball four times for punts, twice for field goals and twice for extra points in the second half.

Sundberg says at one point he grabbed Griffin and told the rookie quarterback to keep the drives going — because the punt snaps were so painful.

Sundberg was wearing a cast on Monday. He's uncertain when he'll be able to play again.

Cardinals QB Skelton gets 'good news'

Arizona Cardinals quarterback John Skelton has a low ankle sprain.

Coach Ken Whisenhunt called the diagnosis "good news," considering Skelton had to be carted off the field in the fourth quarter of Sunday's 20-16 victory over Seattle.

Tests were negative for a fracture and initial concerns were that it would be a more serious high ankle sprain.

Whisenhunt would not speculate on how long Skelton would be sidelined.

Kevin Kolb replaced Skelton and led the team on the winning touchdown drive. Arizona plays at New England next Sunday.