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Philadelphia's Leonard Weaver breaks free of New York defenders and hustles in for a touchdown on the way to a big win for the Eagles. ((Carolyn Kaster/Associated Press) )

Score the first round of the New York-Philly twin bill in favour of the Eagles by brutal knockout.

Donovan McNabb threw three touchdown passes and DeSean Jackson had another big TD catch as the Philadelphia Eagles took a 40-17 win over a mistake-prone Eli Manning and the New York Giants on Sunday.

The game was just the appetizer in a marathon day in the N.Y.-Philadelphia rivalry. The Yankees and Phillies were set for the first pitch of Game 4 of the World Series across the street only hours after the Eagles' rout ended.

The Eagles (5-2) remain undefeated in the NFC East and host Dallas next week, while New York (5-3) has lost three straight games after starting the season 5-0 for the first time since 1990.

Vikings 38, at Packers 26

For the second time in less than a month, Brett Favre sliced up his former team and stuck it to the franchise that cast him aside as the Minnesota Vikings beat the Green Bay Packers at Lambeau Field.

If walking out to waves of loud jeers from his former fans threw Favre off his game, it didn't last long.

Despite being jeered repeatedly by Packers' fans who once cheered his every move, Favre completed 17-of-28 passes for 244 yards and four touchdowns. The Vikings (7-1) took a firm hold on the NFC North standings.

Rookie receiver Percy Harvin caught five passes for 84 yards and a touchdown and had five returns for 175 yards.

The Vikings' defence roughed up Favre's successor, Aaron Rodgers, sacking him six times. But with the Packers (4-3) on the verge of being routed, Rodgers rebounded with three second-half touchdowns.

Panthers 34, at Cardinals 21

The Carolina Panthers earned a measure of revenge over the Arizona Cardinals, even if the stakes weren't quite as high.

Jake Delhomme, whose downward spiral began with a playoff loss at home against Arizona last season, threw a 50-yard touchdown pass before leaving with a chest injury and Jonathan Stewart ran for two scores.

The Panthers (3-4), in a turnover-free performance, rolled up 270 yards on the ground against what had been the No. 1 rushing defence in the NFL.

Arizona's Kurt Warner was intercepted five times and fumbled the ball away once. Julius Peppers returned one of the picks 13 yards for a touchdown.

The Cardinals (4-3) are 1-3 at home.

Broncos 7, at Ravens 30

The Baltimore Ravens handed Denver its first loss by using the same blueprint the Broncos employed to win their first six games.

Rookie Lardarius Webb returned the second-half kickoff 95 yards for a touchdown and the Ravens ended a three-game losing streak with a surprisingly easy 30-7 victory.

It was Denver's first loss under rookie head coach Josh McDaniels.

The Broncos (6-1) came in with the NFL's top-ranked defence, a plus-seven turnover differential and one of the league's best kick returners in Eddie Royal.

Denver had also outscored its opponents 76-10 after halftime.

Baltimore (4-3) limited Denver to 200 yards, scored off the game's lone turnover, won the special teams fight and pulled away after leading by only 6-0 at halftime.

Jaguars 13, at Titans 30

The Tennessee Titans are no longer winless, thanks to a switch to Vince Young at quarterback.

He threw for a touchdown in his first start since the 2008 season opener, Chris Johnson set a franchise record by rushing for 228 yards and the Titans (1-6) won their first game of the season.

Tampa Bay, which had a bye this week, remains the only winless team. Tennessee's skid of eight straight went back to the end of last season.

Johnson helped Young by scoring on runs of 52 and 89 yards, and the Titans eased Young in with lots of short throws and runs to work off any rust. It worked as Young was 15-of-18 for 125 yards and ran 10 times for 32 yards, not counting two final kneeldowns.

Jacksonville (3-4) has lost two of three. Maurice Jones-Drew provided the lone highlights, running for 177 yards and taking the NFL lead in touchdowns rushing with runs of 80 and 79 yards. But the Jaguars gave him only eight carries.

Raiders 16, at Chargers 24

LaDainian Tomlinson scored twice and the San Diego Chargers took their 13th straight victory against the Oakland Raiders. It's the longest active NFL winning streak by one team over another.

The Chargers (4-3) have swept the series for the sixth straight season. Many Chargers, including quarterback Philip Rivers, have never lost to the Raiders (2-6). It was San Diego's seventh straight home win against the Raiders.

San Diego sacked JaMarcus Russell five times, two each for outside linebackers Shaun Phillips and Shawne Merriman.

Tomlinson has accounted for 28 touchdowns against Oakland in his nine-year career: 22 rushing, three receiving and three passing.

Texans 31, at Bills 10

Ryan Moats, taking over after starter Steve Slaton lost yet another fumble, scored three touchdowns on consecutive fourth-quarter drives to help the Houston Texans (5-3) win their third straight game for their best start in franchise history.

Matt Schaub bounced back from two first-half interceptions to lead six scoring drives on seven possessions.

Moats finished with a career-high 23 carries for 126 yards in place of Slaton, who lost a fumble on the Texans' third possession when Paul Posluszny punched the ball out of his hand following a seven-yard reception. Slaton has fumbled seven times this season and lost five.

The Buffalo Bills (3-5) were undone by an offence that managed 204 yards and nine first downs, with only three coming in the second half.

Niners 14, at Colts 18

The Indianapolis Colts won their 16th straight regular-season game on Sunday, the equivalent of an undefeated season.

At the same time Jim Caldwell became the first rookie coach since the NFL merger to open his career with seven consecutive wins thanks to Sunday's 18-14 victory over San Francisco.

Joseph Addai threw his first NFL touchdown pass and Reggie Wayne caught a career-high 12 passes for 147 yards for Indianapolis (7-0).

San Francisco (3-4) lost its third in a row despite a solid performance from Alex Smith, who made his first start in nearly two years. Smith was 19-of-32 for 198 yards with one TD and one interception.

Seahawks 17, at Cowboys 38

Miles Austin caught a touchdown pass for the third straight game and Patrick Crayton returned a punt for a score for the second consecutive week, sending Dallas past the Seattle Seahawks 38-17 and into a share of first place in the NFC East on Sunday.

Tony Romo went a third game in a row without an interception.

Since a herky-jerky first month, the Cowboys (5-2) have found quite a groove, winning three straight, setting up a showdown next Sunday night against the co-leading Eagles in Philadelphia.

Seattle fell to 2-5.

Rams 17, at Lions 10

Steven Jackson's 25-yard touchdown run with 1:38 left lifted St. Louis to a 17-10 win over the Detroit Lions, snapping the Rams' 17-game losing streak.

The Rams (1-7) avoided matching their worst start in franchise history. They also ended talk about joining Detroit as the only teams in NFL history to have an 0-16 season.

St. Louis's key score came on a trick play. It lined up to kick a field goal and had kicker Josh Brown throw a short pass to a wide-open Daniel Fells, whose 36-yard reception gave the Rams a 10-2 lead over the Lions (1-6) in the final minute of the first half.

Dolphins 30, at Jets 25

Ted Ginn Jr. had two long kickoff returns for touchdowns in the third quarter, and the Miami Dolphins held off the New York Jets 30-25.

Miami (3-4) swept the teams' two regular-season meetings 20 days after their first contest, capping a week filled with trash talk from both sides in a re-ignited rivalry.

Facing a fourth-and-13 following a sack by Randy Starks with just over a minute remaining, Mark Sanchez scrambled before firing an incomplete pass over an outstretched Dustin Keller in the end zone to seal it.

Ginn became the first player to return two kickoffs for touchdowns in the same quarter since Green Bay's Travis Williams in 1967

The Jets are 4-4.

Browns 6, at Bears 30

Pounded the previous week and losers of two straight, the Chicago Bears couldn't afford to go down again.

Good thing for them Derek Anderson and the Cleveland Browns were in town.

Jay Cutler threw for 225 yards, Matt Forte ran for two touchdowns and the Bears (4-3) beat the bumbling 1-7 Browns 30-6 on Sunday.