Eli Manning threw for three first-half touchdowns, Ahmad Bradshaw added a pair of rushing touchdowns and the New York Giants routed the Seattle Seahawks 41-7 on Sunday.
Manning and the Giants (6-2) jumped to a 35-0 halftime lead, overwhelming the banged up Seahawks and staking claim as maybe the best team in the NFC halfway through the season.
Manning threw touchdowns of 46 yards to Hakeem Nicks, six yards to Steve Smith and five yards to Kevin Boss. Bradshaw scored on runs of two and four yards.
The Giants rolled up 487 yards of offence against the Seahawks, who gave up 545 total yards last week to Oakland.
Charlie Whitehurst made his first NFL start for Seattle (4-4) and struggled. He was 12 of 23 for 113 yards and two interceptions.
Packers 45, Cowboys 7
Aaron Rodgers threw for 289 yards and three touchdowns, Brandon Jackson scored twice and the Green Bay Packers beat the disintegrating Dallas Cowboys 45-7 on Sunday night at Lambeau Field.
It was a new low point in a lost season for the Cowboys (1-7), who came into 2010 with Super Bowl aspirations. And it's sure to kick off a new round of speculation about the future of coach Wade Phillips, despite recent statements from team owner Jerry Jones that a mid-season firing was unlikely.
James Jones caught eight passes for 123 yards and a touchdown for the Packers (6-3), who have won three straight.
Green Bay's Clay Matthews added a final dose of embarrassment in the fourth quarter, picking off a pass from Jon Kitna and running it back 62 yards for a touchdown.
Eagles 26, Colts 24
Michael Vick threw for 218 yards and one touchdown, ran for 74 yards and a score, and the Eagles beat Peyton Manning and the visiting Indianapolis Colts 26-24.
The Eagles (5-3) are 12-0 after a bye since Andy Reid became coach in 1999. They hadn't beaten Manning in three previous tries.
The Colts (5-3) had to make a quick turnaround after beating Houston on Monday night. It certainly seemed the Eagles were the fresher team, especially early.
The Colts lost wide receiver Austin Collie after a hard — illegal — hit by Kurt Coleman forced him to leave on a stretcher in the second quarter.
Collie lay on the ground for several minutes as the crowd fell silent. Soon afterward, the announcement came he had movement and was alert.
Raiders 23, Chiefs 20
Jason Campbell threw a 47-yard pass to rookie Jacoby Ford in overtime to set up a 33-yard field goal by Sebastian Janikowski that gave the Oakland Raiders their biggest win in eight years, a 23-20 home victory over the AFC West-leading Kansas City Chiefs.
Campbell and Ford hooked up on a 29-yard pass in the closing seconds of regulation to set up Janikowski's tying 41-yard field goal. The Raiders (5-4) then won it in overtime for their most significant victory since winning the 2002 AFC championship.
By winning their third straight game for the first time since that season, Oakland heads into its bye week just a half-game behind Kansas City (5-3) in the division.
Browns 34, Patriots 14
Rookie quarterback Colt McCoy scrambled for a touchdown, Peyton Hillis hammered for a career-high 184 yards and two scores and the Cleveland Browns pounded the New England Patriots 34-14.
Two weeks after stunning New Orleans on the road, the Browns (3-5) pulled off another shocker at home.
Well rested after their bye week, they ended New England's five-game winning streak and did it decisively, outplaying one of the NFL's top teams for all 60 minutes.
This was no fluke. The Patriots (6-2) were battered, baffled and beaten badly.
It had to be particularly satisfying for Browns coach Eric Mangini, who defeated Bill Belichick, his former friend and mentor.
The pair's relationship was damaged years ago and they ignored each other during pre-game warmups. After the game Mangini shared a brief handshake with Belichick.
Ravens 26, Dolphins 10
Billy Cundiff made four field goals, and the Baltimore Ravens cranked up the defence after halftime in a 26-10 home victory over a Miami Dolphins team that was unbeaten in away games.
Baltimore (6-2) won its seventh straight at home behind Cundiff and a defence that blanked Miami (4-4) in the second half. Cundiff connected from 26, 39, 20, 24 yards, and the Ravens held the Dolphins to 24 yards rushing over the final 30 minutes.
Dolphins quarterback Chad Henne went 22 for 34 for 231 yards and three interceptions. Miami came in 4-0 on the road, but the Ravens were seemingly unimpressed. Baltimore never trailed and pulled away after taking a 13-10 halftime lead.
Falcons 27, Buccaneers 21
Michael Turner scored two early touchdowns and the Atlanta Falcons held off Tampa Bay with a gutty goal-line stand, taking over sole possession of first place in the NFC South with a 27-21 home victory.
Turner rushed 24 times for 107 yards, including scoring plays of two and 10 yards that gave the Falcons (6-2) an early 14-0 lead.
Atlanta was hanging on at the end against the Buccaneers (5-3), whose coach, Raheem Morris, had proclaimed his team the best in the NFC.
Not on this day. Tampa Bay had fourth-and-1 from the Atlanta two-yard line with less than three minutes remaining, but LeGarrette Blount was stuffed by Thomas DeCoud on a run over right tackle.
Chargers 29, Texans 23
Philip Rivers threw four touchdown passes against the NFL's worst pass defense, and the visiting San Diego Chargers earned their first road win of the season in beating the Houston Texans 29-23.
Rivers completed 17 of 23 passes for 295 yards. He used eight different receivers in the absence of tight end Antonio Gates, who was out with a right foot injury.
Rookie Seyi Ajirotutu and backup tight end Randy McMichael caught two touchdown passes apiece. Ajirotutu was just moved up to the active roster Oct. 23, when linebacker Kion Wilson went on injured reserve.
The Chargers (4-5) have won two in a row for the first time this season.
Arian Foster rushed 27 times for 127 yards and two touchdown for the Texans (4-4), who have lost three of their last four home games.
Saints 34, Panthers 3
Drew Brees threw for 253 yards and two touchdowns, Jabari Greer returned an interception for a touchdown and the New Orleans Saints became the latest team to shut down Carolina's NFL-worst offence in a 34-3 road victory over the banged-up Panthers.
The Saints (6-3) overcame the loss of tight end Jeremy Shockey to a rib injury after his touchdown catch to keep pace in the competitive NFC South.
Rookie tight end Jimmy Graham caught his first NFL TD in Shockey's absence and the Saints held Carolina to 195 yards.
Things just keep getting worse for the Panthers (1-7). They lost quarterback Matt Moore and running back Jonathan Stewart to first-half injuries.
Vikings 27, Cardinals 24
Brett Favre rallied the Vikings from 14 points down to tie it with 27 seconds to play, then drove them into position for Ryan Longwell's 35-yard game-winning field goal for a 27-24 overtime victory over the visiting Arizona Cardinals.
Favre threw for a career-high 446 yards with two touchdowns and two interceptions for the Vikings (3-5), who fought back cheers of "Fire Childress!" early in the game to pull out the win for their embattled coach.
The Cardinals (3-5) led 24-10 with 4:39 to play thanks to a 96-yard kick return by LaRod Stephens-Howling and a 30-yard fumble return by Michael Adams on another kickoff.
But Favre directed scoring drives of 40 and 77 yards in regulation and Adrian Peterson's 30-yard run in overtime keyed the winning drive.
Jets 23, Lions 20
Mark Sanchez threw a 52-yard pass to Santonio Holmes to set up Nick Folk's 30-yard field goal, lifting the visiting New York Jets to a 23-20 overtime win over the Detroit Lions.
Sanchez scored on a quarterback sneak with 2:46 left in regulation and led a nine-play drive that set up Folk's 36-yard kick to send the game into OT.
Matthew Stafford threw two touchdown passes and ran for a score to give Detroit a 10-point lead before re-injuring his right shoulder and leaving the game with 5:19 left.
The Jets improved to 6-2 while the Lions are 2-6.
Bears 22, Bills 19
Jay Cutler threw two touchdown passes, including one to Earl Bennett late in the fourth quarter to keep the Buffalo Bills winless through eight games and give the Chicago Bears a 22-19 victory in Toronto.
Chester Taylor also scored on a 1-yard plunge for the Bears (5-3), who came out of their off week to end a two-game skid. Tim Jennings' interception came early in the fourth quarter, and with Chicago trailing 19-14.
The game was Buffalo's third regular-season game in Toronto as part of a five-year deal. The Bills have lost all three.