Atlanta Falcons quarterback Michael Vick will not play in the Pro Bowl because he needs to have a bunion on his foot removed.
Vick started 15 games for Atlanta this season, throwing for 2,936 yards and 16 touchdowns.
He also ran for 777 yards and eight scores.
He led the Falcons to a 9-6-1 record in the 2002 regular season and a wild card berth.
Before losing to Philadelphia in an NFC Divisional Playoff contest, Vick threw for 117 yards and a touchdown and rushed for 64 yards as Atlanta stunned Green Bay, 27-7 in the first round of the NFC playoffs at a snowy Lambeau Field.
The 22-year-old Vick joined Dan Marino, Brett Favre, Kurt Warner, Daunte Culpepper and Tom Brady as the only second-year quarterbacks to make the Pro Bowl in their first full season as a starter.
Also expected to skip the NFL's annual all-star game is Kansas City Chiefs running back Priest Holmes, who is nursing a hip injury.
The 29-year-old Holmes, who missed the last two games of the season with the injury, rushed for 1,615 yards caught 70 passes and found the end zone 24 times this season.
Holmes finished his second season with the Chiefs and played four years with Baltimore prior to signing as a free agent with Kansas City.
Over his six-year career, Holmes has played in 78 games, rushing for 5,272 yards and 39.
The Pro Bowl is slated for Feb. 2 in Hawaii