India batsman Sachin Tendulkar was ruled out for the rest of the one-day international series against England on Monday with a toe injury.
The injury leaves Tendulkar still seeking his 100th international century after also missing Saturday's rained-off first ODI at Chester-le-Street.
"It was the [right big toe] injury that he had in 2002 and it flared up in Durham," team manager Shivlal Yadav said. "He went to a specialist in London and we got the news he would not be taking any further part in the one-day series and he might need rest for four to six weeks."
India is trying not to dwell on the impact of losing Tendulkar ahead of Tuesday's meeting with England at the Rose Bowl in Southampton.
"It's something not in our control and which we can't do anything about," said Parthiv Patel, fresh from a career-best ODI innings of 95 on Saturday.
"We just have to try to make sure we make the use of all our resources. You can't fill the shoes of Sachin, no matter who you are.
"So that's obviously a big loss. But it will be a good opportunity for youngsters to prove themselves."
Tendulkar is the eighth player to fly home from India's difficult tour, which saw the tourists trounced 4-0 in a recent test series.
Batsman Rohit Sharma also headed home after fracturing a finger in Saturday's match, although Manoj Tiwary has been called up to take his place.