Florida Gulf Coast 78, Georgetown 68

Sherwood Brown scored 24 points and Bernard Thompson had 23 to lead Florida Gulf Coast to an incredible NCAA tournament debut, a 78-68 win over second-seeded Georgetown on Friday night in the second round of the South Regional at Philadelphia.

The Eagles, in their second season of being eligible for Division I postseason, became just the seventh No. 15 seed to beat a No. 2.

FGCU (25-10) will play the winner of the game between seventh-seeded San Diego State and No. 10 Oklahoma in the third round on Sunday.

A night after America's oldest university, Harvard, pulled off a major upset over fourth-seeded New Mexico, one of its youngest (FGCU's first student was admitted in 1997) got one that was even bigger.

The Eagles took control with a 21-2 run that gave them a 52-33 lead with 12:28 to play, though the Hoyas used a furious rally to get within 72-68 with 52 seconds left.

It was another disappointing NCAA exit for the Hoyas (25-7), who have lost to a double-digit seed in their last four appearances.

Markel Starks had 23 points for the Hoyas.

Kansas 64, Western Kentucky 57

Jeff Withey scored 17 points and top-seeded Kansas struggled to put away scrappy Western Kentucky in a 64-57 victory Friday night that avoided what would have been the biggest upset on a day full of them in the NCAA tournament.

The Jayhawks (30-5), flummoxed by the Hilltoppers' full-court pressure, trailed 31-30 at halftime. Kansas eventually built an 11-point lead in the second half, but couldn't put Western Kentucky away until Ben McLemore's two foul shots with 11 seconds left in the game.

McLemore and Travis Releford scored 11 each for the Jayhawks (30-5), who wearily advanced to play No. 8 seed North Carolina and former coach Roy Williams in the South Regional on Sunday.

Jamal Crook scored 13 points and T.J. Price had 12 for the Hilltoppers (20-16), who would have made history by becoming the first No. 16 seed to upend a No. 1 seed in the tournament.

Duke 73, Albany 61

Seth Curry scored 26 points, Mason Plumlee had 23 to lead second-seeded Duke in the second round of the Midwest Regional in Philadelphia. 

The Blue Devils (28-5) will meet the winner of the game between seventh-seeded Creighton and 10th-seeded Cincinnati in the third round Sunday at the Wells Fargo Center.

Duke shot 58.7 per cent (27 of 46), just off its season-beat 60.8 percent against Florida State.

The Blue Devils, who lost 75-70 to 15th-seeded Lehigh in the second round last year, never really pulled away from the Great Danes (24-11), who got as close as eight points with 4:40 to play.

Duke coach Mike Krzyzewski extended his all-time lead with his 80th career victory in the tournament that he has won four times. Jacob Iati had 15 points for Albany, which was making its third NCAA appearance, all since 2006.

Creighton 67, Cincinnati 63

Doug McDermott had 27 points and 11 rebounds, and Gregory Echenique scored 13 points to help Creighton hold on to beat Cincinnati 67-63 on Friday in the second round of the Midwest Regional.

Ethan Wragge added 12 for the Bluejays, who won their NCAA tournament opener for the second straight year.

McDermott, the two-time Missouri Valley Conference player of the year and 2012 All-American, made all 11 free throws to help the seventh-seeded Bluejays (28-7) move on to play Duke on Sunday.

Sean Kilpatrick's driving layup after Cincinnati had the arrow on a jump ball cut it to 64-63 with 17 seconds left. Austin Chatman sank two free throws for Creighton. Kilpatrick's attempt at a tying 3 rimmed out, and the Bearcats were whistled for traveling after grabbing the rebound.

Chatman then hit one of two from the line to clinch it.

Ole Miss 57, Wisconsin 46

Marshall Henderson shook out of a shooting slump and scored 17 points in the second half, leading 12th-seeded Mississippi past No. 5 Wisconsin, giving the Rebels their first NCAA tournament win since 2002.

For the cold-shooting Badgers (23-12), the upset loss snaps a string of six straight first-game victories. Ole Miss (27-8) trailed 25-22 at halftime and Henderson, who led the Southeastern Conference with 20 points a game, had only two points on one-for-11 shooting.

But the flamboyant and outspoken guard found his touch just in time for Ole Miss, and wound up hitting 6 of 21. His back-to-back 3-pointers tied it 36-36 and his layup and two free throws in the final minute sealed the win.

Reginald Buckner had nine points and 12 rebounds in the game in Kansas City, Mo. Sam Dekkar had 14 points for Wisconsin.

In the third round of the West Regional on Sunday, the Rebels will play the winner of the matchup between No. 4 seed Kansas State and No. 13 La Salle.

LaSalle 63, Kansas State 61

La Salle wouldn't let a stellar first half go to waste.

Jerrell Wright made three foul shots in the final 30 seconds, and the No. 13 seed Explorers survived after blowing an 18-point halftime advantage to beat fourth-seeded Kansas State 63-61 on Friday in the second round of the NCAA tournament.

Wright, who scored a game-high 21 points for the Explorers (22-9), made the first two free throws to give La Salle a 62-61 lead. Kansas State's Jordan Henriquez missed in the paint at the other end, and Wright made the first of two more foul shots with 9.6 seconds to go.

The Wildcats (27-8) raced down court, looking for a tying basket, but point guard Angel Rodriguez got hung up in the corner near the Kansas State bench. His off-balance shot over the corner of the backboard missed everything, and the Explorers jumped off their bench to celebrate.

Ramon Galloway scored 15 of his 19 points in the first half, and Sam Mills added 10 points for La Salle, which beat Boise State in one of the First Four games just to reach Kansas City, and now has won two games in the NCAA tournament for the first time since 1955.

The Explorers will play 12th-seeded Mississippi, which knocked off No. 5 Wisconsin 57-46 earlier in the day, for a spot in the round of 16 in a suddenly shredded West Region.

Indiana 83, James Madison 62

Yogi Ferrell scored Indiana's first nine points and had 14 in the first six minutes as the top-seeded Hoosiers powered to an easy 83-62 win in the second round of the East Regional on Friday.

Not taking any chances with a No. 16 seed, the Hoosiers (28-6) started fast, building a 21-point halftime lead. They pushed it to 33 in the second half before letting up and had little trouble with the Dukes (21-15), who won their first tournament game in 30 years on Wednesday and thought they could hang with the Hoosiers.

Looking every bit like a team capable of cutting down the nets in Atlanta next month, Indiana, which spent a good chunk of the season atop the AP poll, will play Temple in the second round on Sunday.

Will Sheehey scored 15 and Cody Zeller 11 — eight on rim-rocking dunks — for Indiana.

Freshman Andre Nation scored 24 and Charles Cooke 18 for James Madison, which made the score somewhat respectable in the final minutes but never really threatened.

Illinois 57, Colorado 49

For Colorado, the NCAA tournament was all about momentum.

The Buffaloes were making consecutive appearances for the first time in 50 years. As a No. 10 seed in the East, they were a trendy pick for a mild upset over No. 7 seed Illinois at Austin. They even fought back from a 16-point deficit with a 21-0 run in the second half to take the lead.

But all that momentum disappeared in one 30-second span late in the game when Illinois made consecutive 3-pointers to regain the lead and pull away for a 57-49 victory Friday.

The Illini (23-12) advanced to play Sunday against No. 2 seed Miami. Colorado (21-12) has to go back home.

Ohio State 95, Iona 70

Sam Thompson had career highs with 20 points and 10 rebounds on Friday night, part of a dominating performance by Ohio State's front line, and the Buckeyes ran away to a 95-70 victory over Iona in the second round of the West Regional.

The second-seeded Buckeyes (27-7) are in prime March form with nine straight wins, including their last five games in the regular season and a run to the Big Ten tournament title.

Forward Deshaun Thomas has led them in scoring during the streak, averaging 17.6 points. He had 24 points as the Buckeyes' fast breaks led to dunks and a season high in points, thrilling the large Ohio State contingent.

Iona (20-14) returned to the court where it suffered the biggest meltdown in NCAA tournament history last year, blowing a 25-point lead. The Gaels are 1-9 all-time in the tournament with their only win, over Holy Cross in 1980, later vacated because of NCAA violations.

Miami 78, Pacific 49

Durand Scott had 21 points and Miami had a triumphant return to the NCAA tournament with a 78-49 victory over Pacific on Friday.

The Hurricanes (28-6), who may be even better than their No. 2 seed in the East Regional would indicate, put the game out of reach with a 14-0 run midway through the first half of their first NCAA tourney game in five years.

Pacific (22-13), the California team that played its last game for retiring longtime coach Bob Thomason, was no match for the Atlantic Coast Conference's regular season and tournament champions.

After Khalil Kelley's three-point play with 14:35 left in the first half got them within 8-7, the Tigers went more than 7 minutes without scoring. Shane Larkin, the ACC player of the year, started the Miami run with two free throws, an alley-oop pass and a three-point play.

Temple 76, North Carolina State 72

Khalif Wyatt scored 31 points, finishing the game with an injured left thumb that had him grimacing before his decisive free throws, and Temple broke with its trend of opening game losses in the NCAA tournament on Friday, beating North Carolina State 76-72 in the second round of the East Regional.

The ninth-seeded Owls (24-9) will face Indiana on Sunday, which represents a breakthrough for Temple right there.

The Owls are trying to shed its reputation as an easy-out team. They'd made the tournament each of the last five years, losing their opening game all but once. They haven't been to the round of 16 since 2001, when they reached the Elite Eight.

North Carolina 78, Villanova 71

P.J. Hairston scored 23 points, James Michael McAdoo added 17 and North Carolina unleashed a flurry of 3-pointers to subdue gritty Villanova 78-71 in the NCAA tournament Friday night, giving coach Roy Williams his 700th career victory.

The never-say-die Wildcats (20-14) erased a 20-point deficit that North Carolina built in the first half and then nearly climbed out of a nine-point hole in the final minutes after the Tar Heels hit three consecutive 3s and once again appeared to take control.

Florida 79, Northwestern State 47

Erik Murphy had 18 points to lead four Florida players in double figures and the Gators shut down the NCAA's highest-scoring team.

No. 3 seed Florida turned this one into a rout with a 19-1 run in the second half and held the 14th-seeded Demons (23-9) to their fewest points this season, 34 below their average.

Patric Young had 16 points and nine rebounds for Florida (27-7). Kenny Boynton and Scottie Wilbekin both scored 11.

DeQuan Hicks had 12 points for the Demons, who upset Iowa as the No. 14 seed in their last NCAA tournament seven years ago. They couldn't repeat that feat against the Gators, who lost in the regional finals each of the past two seasons.

Iowa State 76, Notre Dame 58

Freshman Georges Niang matched a season high with 19 points and Iowa State, showing it can do much more than just fire away from outside the 3-point line, dismantled Notre Dame 76-58 on Friday night in the NCAA tournament.

The 10th-seeded Cyclones (23-11) will play No. 2 seed Ohio State on Sunday. The Buckeyes advanced with a 95-70 thrashing of Iona.

Iowa State led the nation in 3-pointers this season, but the Cyclones were just as effective from short range in ousting the Fighting Irish (25-10), who played their final game as a member of the Big East and will join the Atlantic Coast Conference next season.

Melvin Ejim added 17 points for Iowa State, which shot better than 70 per cent for much of the second half.

Tom Knight scored 14 to lead the Fighting Irish.

San Diego State 70, Oklahoma 55

Jamaal Franklin scored 21 points, James Rahon had 17 and San Diego State beat Oklahoma 70-55 on Friday night to earn its third NCAA tournament victory.

The seventh-seeded Aztecs (23-10) will play No. 15 seed Florida Gulf Coast on Sunday in the South Regional. The Eagles introduced themselves to the college basketball world with a 78-68 win over Georgetown.

After that thriller, this game never stood a chance.

The Aztecs did nothing spectacular, but everything well and used a modest 8-0 run late in the second half to snap a tie game and take control.

Romero Osby scored 22 points for the 10th-seeded Sooners (20-12).

Minnesota 83, UCLA 63

Andre Hollins scored 28 points and Minnesota rolled past punchless UCLA 83-63 on Friday night in the second round of the NCAA tournament, a game that could be Bruins freshman Shabazz Muhammad's last in college and coach Ben Howland's final one leading the program.

Austin Hollins scored 16 for the 11th-seeded Gophers (21-12), who advanced to Sunday's third round against No. 3 seed Florida in the South Regional. The Gophers eased some pressure on coach Tubby Smith by giving him his first NCAA tournament win in six seasons.

Another early-round exit by the sixth-seeded Bruins (25-10) won't help Howland, who is facing public speculation back home about his future despite winning the Pac-12 regular-season title this year.

Muhammad, expected to leave for the NBA, led the Bruins with 20 points.