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Nick Swisher celebrates his two-run home run on Thursday against the Chicago White Sox. ((Kathy Willens/Associated Press))

NEW YORK — Brett Gardner led off the Yankees' six-run fifth inning with a homer for their first hit of the game, and Nick Swisher homered and had four RBIs in New York's 12-3 rout of the Chicago White Sox on Thursday night.

CC Sabathia pitched seven sharp innings to beat a familiar foe and help New York gain a split of the four-game series. Swisher hit his first homer in 76 at-bats this season and he, Nunez and Gardner scored three runs apiece. Every Yankees starter except Nunez had at least one RBI.

Curtis Granderson tripled, Alex Rodriguez and Nunez each hit a double, and Swisher broke an 0-for-19 slump with a single in the fifth. New York sent nine batters to the plate before making an out in the inning.

Red Sox 6, Orioles 2

BALTIMORE  — Jon Lester improved to 14-0 all-time against Baltimore with eight dominating innings, Dustin Pedroia hit a tiebreaking infield single and the Boston Red Sox averted a three-game sweep with a 6-2 victory over the Orioles on Thursday night.

Lester (3-1) is unbeaten in 17 career starts versus the Orioles. He yielded two runs on four hits, walked three and struck out five.

After Derrek Lee's RBI single in the first, the left-hander didn't allow another hit until Vladimir Guerrero's solo homer in the sixth.

It was 2-2 when Carl Crawford doubled off Jim Johnson (1-1) to the start the seventh. Crawford held second when Marco Scutaro couldn't execute a sacrifice bunt, took third on Jacoby Ellsbury's grounder and scored when third baseman Mark Reynolds bobbled Pedroia's slow roller.

Mariners 7, Tigers 2

DETROIT — Rookie Michael Pineda struck out nine in six sharp innings, and Miguel Olivo and Luis Rodriguez homered to help Seattle beat Detroit for a three-game sweep.

Ichiro Suzuki added two hits, and Justin Smoak hit an RBI double in the fourth inning that put Seattle ahead to stay. The Mariners swept a three-game set against Detroit for the first time since July 2003.

Pineda (4-1) struck out the first four batters he faced and finished with nine in six innings. Although he allowed a couple runs in the second inning, the 6-foot-7 right-hander was overpowering at times.

Brad Penny (1-3) was the loser.

Indians 8, Royals 2

CLEVELAND  — Fausto Carmona, backed by four solo home runs, pitched seven solid innings and the Cleveland Indians earned their 10th straight home win by beating Kansas City 8-2 on Thursday night to extend the Royals' losing streak to six.

Carmona (2-3) allowed two runs and five hits as Cleveland opened a 4 ½-game lead over the Royals and Detroit Tigers in the AL Central. The right-hander walked two and struck out two.

Shin-Soo Choo and Carlos Santana connected for consecutive homers with two outs in the first inning off Kyle Davies (1-3). Grady Sizemore opened the third with his fourth homer and Shelley Duncan, a late lineup addition when designated hitter Travis Hafner was scratched with an inflamed right ankle, began the fourth with his first of the year to make it 4-0.