He finished with 106 yards on three catches to post his second straight 1,000-yard receiving season.
The 121 receiving yards was the most for Thomas since the season-opener, when he gained 161 yards on five catches.
Thomas proved nearly unstoppable against the Chargers' weak secondary. He has now scored in three straight weeks and should remain a top-five option down the stretch. His nine TD receptions are tied with Calvin Johnson and teammates Julius Thomas and Wes Welker for second in the NFL.
Thomas has 29 catches for 393 yards and four scores for the Broncos. He ranks in the league's top 10 in all three categories.