Charles caught eight passes for 195 yards and four touchdowns in the most productive receiving day by a running back since Marshall Faulk had 204 yards in 1999 against Chicago. Charles also had 20 yards rushing and joined Shaun Alexander, Jerry Rice and Clinton Portis as the only players since the merger to score five touchdowns and gain at least 200 yards from scrimmage in a single game.
He has three TDs in the last two games. He also became the fifth Chiefs player with 1,000 attempts in his career and the first with four 1,000-yard seasons.
The running back also had four catches for 42 yards.
Though Charles has 725 rushing yards this season, he only has one 100-yard game.
He left the game briefly with a bruised knee, and he didn't reach the end zone after scoring four times in his last three games.
It wasn't clear which knee Charles hurt or when it occurred. He was questionable to return. Charles had been having another nice game, carrying 11 times for 54 yards, and hauling in three catches for 35 yards in helping Kansas City to a 20-10 halftime lead.
Charles leads the team with 475 rushing yards and 300 yards receiving.
"As a quarterback I've had my fair share of blisters," said QB Alex Smith, "but nothing that looks like his. You develop your own secret to get through them." Charles wasn't available in the locker room Wednesday.
Charles appears to fit coach Andy Reid's scheme perfectly as many prognosticators expected. He's already caught 28 passes through five games and should shatter his career-high of 45 receptions, set in 2010.
Charles should be able to go against the Titans this Sunday.