Team officials said he would not return, leaving the Chiefs without their top offensive player. Charles was hurt on his third carry of the game Saturday and stayed down on the ground for several minutes before walking off the field under his own power. Team trainers tended to him on the sideline, doing what appeared to be concussion tests, before walking with Charles into the locker room.
After doing most of his damage last week in the receiving game, he returned to the ground this week. He has at least one rushing TD in his last five games.
Charles caught eight passes for 195 yards and four touchdowns in the most productive receiving day by a running back since Marshall Faulk had 204 yards in 1999 against Chicago. Charles also had 20 yards rushing and joined Shaun Alexander, Jerry Rice and Clinton Portis as the only players since the merger to score five touchdowns and gain at least 200 yards from scrimmage in a single game.
He has three TDs in the last two games. He also became the fifth Chiefs player with 1,000 attempts in his career and the first with four 1,000-yard seasons.
The running back also had four catches for 42 yards.
Though Charles has 725 rushing yards this season, he only has one 100-yard game.
He left the game briefly with a bruised knee, and he didn't reach the end zone after scoring four times in his last three games.
It wasn't clear which knee Charles hurt or when it occurred. He was questionable to return. Charles had been having another nice game, carrying 11 times for 54 yards, and hauling in three catches for 35 yards in helping Kansas City to a 20-10 halftime lead.
Charles leads the team with 475 rushing yards and 300 yards receiving.
"As a quarterback I've had my fair share of blisters," said QB Alex Smith, "but nothing that looks like his. You develop your own secret to get through them." Charles wasn't available in the locker room Wednesday.
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