Brees was 20 of 30 for 250 yards with a TD and two interceptions in New Orleans' wild-card win over Philadelphia on Saturday.
The Saints were able to prevail despite a generally lackluster effort from their quarterback, with Brees matching his third-lowest passer rating of the regular season.
Brees was his usual prolific self, passing for four touchdowns and even running for a score as New Orleans concluded the regular season 8-0 at home Sunday with a win over Tampa Bay.
Brees passed for 381 yards, eclipsing 5,000 yards in a season for an unprecedented fourth time. He finished the season with 5,162 yards to go with 39 touchdowns.
Brees completed 30 of 44 passes for 281 yards and a touchdown in Sunday's loss to Carolina.
The Saints have lost consecutive games, and Brees has thrown two TDs and four interceptions in the losses.
Brees passed for 313 yards and four touchdowns and New Orleans beat Carolina 31-13 on Sunday night to regain sole possession of first place in the NFC South and snap the Panthers' winning streak at eight games.
Brees became the fifth quarterback to eclipse 50,000 career yards passing.
Brees threw a TD, but finished 23 of 38 for a season-low 147 yards in Monday's lost against the Seahawks. He also fumbled after his arm was hit and that was returned for a TD.
Brees and the Saints were stymied the entire game, with the star quarterback losing for the first time on Monday night after nine straight wins.
Brees went 30 of 43 (69.8 percent) for 305 yards in New Orleans's 23-20 win over the 49ers. Brees threw one touchdown and one interception as well.
Though his only touchdown pass was in the first quarter, Brees was still vital to the Saints winning the game at the end. He led New Orleans on three fourth-quarter scoring drives, including the one that set up Garrett Hartley's 31 yard field goal as time expired.
Brees completed 34 of 41 passes for 392 yards and four touchdowns, and the New Orleans Saints beat the Dallas Cowboys 49-17 on Sunday night. The Saints (7-2) produced an NFL-record 40 first downs and a franchise-record 625 total yards.
Brees has topped 330 yards in three straight games, and he has 11 touchdowns to two interceptions during that stretch.
Brees was 30 of 51 for 382 yards with two TDs to Jimmy Graham, but was also intercepted by Demario Davis and Antonio Cromartie and sacked twice in Sunday's loss to the Jets.
Brees has just seven interceptions aside 21 TDs, so his numbers are still strong.
Brees struck for five touchdown passes in a 35-17 victory over the Buffalo Bills on Sunday.
Brees finished 26 of 34 for 332 yards, completing passes to 10 targets. He owns the NFL record with eight career games with five or more TD passes.
Brees completed 17 of 36 passes for 236 yards with two interceptions and one interception Sunday against the Pats.
This was his lowest-passing game of the year.