Neither Cleveland nor Chicago could generate much offense in their series opener.
The Indians won in dramatic fashion, but could have another tough time at the plate when they face White Sox staff ace Chris Sale on Saturday.
Friday was a pitchers' duel in Cleveland, with Justin Masterson besting Jose Quintana by tossing a five-hitter in a 1-0 victory. The Indians (4-5) won when Nick Swisher drove in Michael Bourn from third on a two-out single in the ninth inning off Jesse Crain.
"It would have been a shame for us to not go out and get Masty that win,'' Swisher said.
Instead, it was the White Sox (4-6) that left Quintana without a victory. He yielded one hit without a walk in seven innings and struck out seven - the same as Masterson.
Quintana became the second straight left-hander to frustrate the Indians after Andy Pettitte allowed a run and five hits over seven innings in Tuesday's loss to the New York Yankees. Another southpaw is up next.
After throwing 7 2-3 innings in a 1-0 win over Kansas City on opening day, Sale (1-0, 1.84 ERA) gave up three runs - on a two-run homer to Michael Morse and a solo shot to Kendrys Morales - in seven innings of Sunday's 4-3, 10-inning win over Seattle. He allowed five hits in all and struck out seven in his second straight outing.
"It wasn't his best day as far as command and even stuff, but that's how good he is where he can shut down a pretty good offense like that and keep us in the game and give us a chance,'' catcher Tyler Flowers said.
This will be the third time in as many starts Sale is taking the ball during the day. Since the start of last season, his 2.64 day ERA is the second-best in the AL among those with at least 10 starts in the afternoon.
He made three starts against the Indians last season, going 2-0 with a 2.29 ERA.
Swisher is 0 for 5 with three strikeouts lifetime against Sale, and Bourn is 1 for 8.
Bourn had one of Cleveland's three hits Friday, and has hit safely in seven of eight games, batting .333 (12 for 36).
The Indians avoided their first 0-3 home start since 1996, and sent Chicago to its first 0-4 road start since 1978. The White Sox haven't dropped their first five away from Chicago since 1972.
The White Sox opened the season by hitting 11 homers during a 4-2 start at U.S. Cellular Field, but have two home runs since.
Paul Konerko, who doubled Friday, and third baseman Conor Gillaspie, who also doubled as part of a third straight multihit game, have both been enjoying success at the plate.
Konerko is 5 for 13 (.385) with a homer and four RBIs during the skid, but is 1 for 9 lifetime against scheduled starter Zach McAllister (0-1, 3.00).
McAllister was originally scheduled to start Thursday against the Yankees, but has been bumped back due to consecutive rainouts. In his lone outing, he gave up four runs and six hits in six innings of a 4-0 loss to Tampa Bay on April 5. He didn't issue a walk but threw two wild pitches.
"It wasn't terrible, but wasn't my best outing," said the right-hander, who has gone 1-0 with a 3.12 ERA in three career starts against the White Sox.