BOSTON (AP) Jon Lester outdueled Max Scherzer and Boston beat Detroit 2-1 on Tuesday night, ending the Tigers right-hander's chance to become just the second pitcher to open a season with a 20-1 record.
Lester (13-8) lowered his ERA to 1.71 in his past six starts. He allowed one earned run and eight hits with a season-high nine strikeouts and no walks.
Scherzer (19-2), who won his first 13 decisions, lost for the first time since July 13 when Texas beat him 7-1.
Roger Clemens is the only pitcher to start 20-1. He ended up 20-3 with the Yankees in 2001.
Boston scored on Will Middlebrooks' two-run single in the fifth. Detroit's Jose Iglesias doubled in a run in the second in the matchup of division leaders.
Koji Uehara pitched the ninth for his 17th save in 20 opportunities and extended his scoreless streak to 25 innings.
Miguel Cabrera, who missed three games with abdominal and groin problems, returned for Detroit and went 0 for 4.
Yankees 6, White Sox 4
NEW YORK (AP) - Eduardo Nunez's two-run double capped a five-run eighth inning for New York.
Pinch-hitter Curtis Granderson tied the score with an RBI single off reliever Donnie Veal and New York went on to win for the 12th time in 14 home games.
Alexei Ramirez hit a two-run triple and Alejandro De Aza homered for the last-place White Sox who dropped their fifth straight.
Alfonso Soriano's two-run single off Nate Jones (4-5) cut the deficit to 4-3.
Boone Logan (5-2) pitched a perfect eighth, and Mariano Rivera earned his 40th save.
Derek Jeter finished with two hits, giving him 3,315 to pass Eddie Collins (3,313) for ninth on the career list.
Indians 4, Orioles 3
CLEVELAND (AP) - Ubaldo Jimenez pitched six shutout innings while Yan Gomes and Asdrubal Cabrera drove in two runs apiece, and Cleveland survived a shaky ninth inning.
Jimenez (10-9) has allowed three earned runs or less in eight consecutive starts. The right-hander allowed four hits.
Gomes' two-run double was the key hit in Cleveland's sixth. Cabrera had sacrifices flies in the fourth and sixth.
Orioles starter Chris Tillman (15-5) allowed four runs in 5 1-3 innings. The right-hander has one win in his last six starts.
The Orioles got back in the game in the ninth against Indians closer Chris Perez, who pitched in a non-save situation. Nate McLouth hit a three-run homer but Perez struck out Brian Roberts and Manny Machado before retiring Chris Davis, who leads the majors with 47 homers, on a ground ball.