Saturday December 30, 2017
1st ever gene-edited human embryo raises ethical concerns
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- Meteorites could be the reason we walk the Earth today
- Mysterious empty chamber found in the Great Pyramid of Giza
- 'Shockingly successful' artificial womb could save thousands of infant lives
- 'For the first time ever, we have a piece of another star system,' astronomer announces
- 1st ever gene-edited human embryo raises ethical concerns
- Full Episode
First human case
This year, scientists say they successfully corrected an inherited gene mutation in a human embryo responsible for a type of heart disease. While the procedure has great potential, it also raised questions about safety and ethics of manipulating the human genome.
Dr. Shoukhrat Mitalipov, principal investigator at the Center for Embryonic Cell an Gene Therapy of Oregon Health & Science University, says the procedure can only be done on sperm or eggs that parents pass on to children.
Why edit embryos?
In this case, the idea was to correct a mutation that encodes for heart muscle and leads to hypertrophic cardiomyopathy. Once the child is born, often there's already too much damage to the organs or tissue to correct the mutation and change it back to normal, Mitalipov said.
He said scientists could use a similar approach of using the gene editing tool called CRISPR to recognize and flag the mutant gene in sperm. Once that happens and the egg is about to be fertilized or at that time, the egg's own DNA repair mechanism kicks in to glue back the broken piece and repair any abnormality.
Safety and ethical concerns
Mitalipov acknowledged that off-target effects that they haven't identified are still possible, which is investigators need to perform more safety tests before they attempt clinical trials.
He called concerns about the experiment opening the floodgate to human eugenics and designer babies legitimate ones that need to be regulated.