Two people died and more than 80 were hurt when at least 140 vehicles collided on a Texas highway in dense fog, leaving trucks twisted on top of each other and authorities rushing to pull survivors from the wreckage.

"It is catastrophic," said Jefferson County Sheriff's Office Deputy Rod Carroll. "I've got cars on top of cars."

The Thursday morning crash happened on Interstate 10, 128 kilometres east of Houston.

Carroll said 80 to 90 people were transported to hospitals, with 10 to 12 of those in serious to critical condition. He said 140 to 150 vehicles were involved in the pileup.

Carroll said the fog was so thick that officers didn't immediately realize they were dealing with multiple accidents.

According to the Texas Department of Public Safety, a crash on the eastbound side of the highway led to other accidents in a dangerous chain reaction. There were multiple crashes on the other side of the highway as well.

DPS trooper Stephanie Davis told KFDM that two people were killed in an SUV crushed by a tractor trailer. She said at least 100 cars and trucks were involved in the accident.

Davis identified the dead as Debra Leggio, 60, and Vincent Leggio, 64.

I-10's eastbound lanes were re-opened Thursday evening after more than eight hours.

Carroll said uninjured drivers tried to help as authorities sorted through the wreckage.

"It's just people helping people," Carroll said. "The foremost thing in this holiday season is how other travellers were helping us when we were overwhelmed, sitting and holding, putting pressure on people that were injured."