Early-stage sperm cells created from bone marrow: study
Last Updated: Friday, April 13, 2007 | 1:51 PM ET
CBC News
Related
Scientists have created early-stage sperm cells from human bone marrow, a development that a researcher says could one day lead to improvements in fertility treatments.
In a study published Friday, Professor Karim Nayernia of the University of Newcastle on Tyne in Britain and a team of researchers said they were able to create spermatagonial cells, which in most men develop into fully functional sperm, from stem cells in the bone marrow of human male volunteers.
However, the spermatagonial cells in the experiment did not turn into sperm cells, a process Nayernia hoped could be reached after more experimentation.
"Our next goal is to see if we can get the spermatagonial stem cells to progress to mature sperm in the laboratory and this should take around three to five years of experiments," Nayernia said in a statement.
The next step for these early-stage cells to become sperm would be for them to undergo meiosis — or cell division. Earlier experiments were able to achieve this step using cells from bone marrow in mice. These cells also did not develop into fully mature sperm.
The research, published in the journal Reproduction: Gamete Biology, could one day help in fertility treatment for men, Nayernia contends.
And if female bone marrow is also able to produce sperm cells, it raises the possibility that women would be able to pass on their genetic material through manufactured sperm.
Nayernia told the British newspaper the Telegraph that growing sperm from females is possible, based on evidence from testing of mice.
The process could run into legal concerns in the U.K., with a recent government white paper proposing a ban on using artificially created sperm or eggs in assisted reproduction.
Though any advances are likely far off, University of Alberta law professor Tim Caulfield told CBC News Online Canadian regulators should start thinking about where artificially created sperm would fall under the law.
Buying reproductive material not allowed
The Assisted Human Reproduction Act allows the donation of sperm and eggs and their use to assist conception and allows the use of human stem cells in research. But buying or selling sperm, eggs and other human reproductive material is not allowed.
"If these cells are defined as naturally created, they would likely fall under the act and be subject to the same rules," said Caulfield, a Canada Research Chair in Health Law and Policy.
"But if they are found to be outside the normal definition, then we'll need to figure out how they can be used," he said.
Last year, Nayernia and scientists at the University of Gottingen in Germany became the first to produce viable artificial sperm from embryonic mouse stem cells. These sperm were used to fertilize mice eggs, resulting in seven live births.
Stem cells have the unique ability to develop into any type of cell, with embryonic stem cells considered the most versatile kind.
Share Tools
Top News Headlines
- Montreal protesters march in peaceful defiance
- The clanging of pots and pans sounded throughout Montreal's downtown core Saturday night and into early Sunday morning, as thousands of protesters marched on in peaceful — but loud — defiance of Bill 78. more »
- Quebec tornadoes cause millions in damage
- Environment Canada confirms that two tornadoes — one of which was classed as a moderate F-1 packing winds of up to 150 km/h — touched down near Montreal Friday night, causing millions of dollars in damage. more »
- Teen struck by lightning in Ottawa dies
- The victim of a Friday lightning strike during a storm in east Ottawa has died, CBC News has learned. more »
- Ryder wins! Hesjedal makes history at Giro
- Ryder Hesjedal has made history. The Victoria, B.C. native became the first Canadian to win one of three Grand Tour events, on Sunday, wrapping up the 2012 Giro wth an excellent performance in the 21st and final stage at Milan. more »
Latest Health News Headlines
- Alcohol addiction team wants higher energy drink prices
- Mixing alcohol with caffeine-rich energy beverages is a trend that is continuing to rise in Canada, despite repeated warnings that the combination is unsafe, a new report warns. more »
- How curry spice helps the immune system kill bacteria
- A spice used in curry dishes helps to prevent infection and now scientists think they've got a lead on how. more »
- Calgary EMS station opens to the public
- Curious Calgarians got a look at a northwest EMS station this morning. more »
- Yellowknife toddlers catching hand, foot and mouth virus
- An outbreak of hand, foot and mouth disease in Yellowknife is causing many toddlers and their parents some major discomfort. more »
FEATURED HEALTH
- Teen struck by lightning in Ottawa dies
- Missing Winnipeg children found in Mexico
- Quebec tornadoes cause millions in damage
- Montreal protesters march in peaceful defiance
- Woman's remains found in hockey bag on Cape Breton river
- Outrage grows over Syria killings
- Pope's butler arrested in Vatican leaks scandal
- Everest team unable to bring down Toronto woman's body
- WWE apologizes to Brazil over Canadian's flag stomp

