Japanese scientist wins 2016 Nobel Prize in Medicine
Molecular biologist Yoshinori Ohsumi hailed for 'brilliant experiments' in autophagy
Japanese scientist Yoshinori Ohsumi was awarded this year's Nobel Prize in Medicine on Monday for discoveries related to the degrading and recycling of cellular components.
The Karolinska Institute honoured Ohsumi for "brilliant experiments" in the 1990s on autophagy, the machinery with which cells recycle their content.
Autophagy ”self eating” is a process for degrading and recycling cellular components <a href="https://twitter.com/hashtag/NobelPrize?src=hash">#NobelPrize</a> <a href="https://twitter.com/hashtag/Medicine?src=hash">#Medicine</a> <a href="https://t.co/glNWLPjxHe">pic.twitter.com/glNWLPjxHe</a>—@NobelPrize
The organelle autophagosome engulfs cellular contents and fuses with the lysosome, where the contents are degraded. <a href="https://twitter.com/hashtag/NobelPrize?src=hash">#NobelPrize</a> 2016 <a href="https://t.co/FBNpB5ksow">pic.twitter.com/FBNpB5ksow</a>—@NobelPrize
Ohsumi studied thousands of yeast mutants and identified 15 genes that are essential for autophagy. <a href="https://twitter.com/hashtag/NobelPrize?src=hash">#NobelPrize</a> <a href="https://t.co/WbheUJIDPA">pic.twitter.com/WbheUJIDPA</a>—@NobelPrize
Disrupted autophagy has been linked to various diseases, including Parkinson's, diabetes and cancer, the institute said.
Ohsumi's work has led to a better understanding of how the human body adapts to starvation, infection and other conditions.
Though the concept has been known for more than 50 years, its "fundamental importance in physiology and medicine was only recognized after Yoshinori Ohsumi's paradigm-shifting research in the 1990s," Karolinska said in its citation.
Ohsumi was born in 1945 in Fukuoka. He is currently a professor at the Tokyo Institute of Technology.
It was the 107th award in the medicine category since the first Nobel Prizes were handed out in 1905.
Ohsumi generated an enormous interest in autophagy and is now one of the most intensely studied areas of biomedical research <a href="https://twitter.com/hashtag/NobelPrize?src=hash">#NobelPrize</a> <a href="https://t.co/sRp3IylW8m">pic.twitter.com/sRp3IylW8m</a>—@NobelPrize
Last year's prize was shared by three scientists who developed treatments for malaria and other tropical diseases.
The announcements continue with physics on Tuesday, chemistry on Wednesday and the Nobel Peace Prize on Friday. The economics and literature awards will be announced next week.
Each prize is worth the equivalent of about $1.224 million Cdn (eight million kronor).
- An earlier version of this article said eight million kronor equal $14,200 Cdn. In fact, the prize total amounts to about $1.224 million Cdn.Oct 03, 2016 7:56 AM ET