A 24-year-old Windsor woman is in police custody after an early Sunday morning confrontation with a man in the downtown core, police say.

The man and his friend walked away from the altercation, but police report the woman then went to her car and ran both men over in a nearby parking lot on Pelissier Street, south of Wyandotte Street.

Both men were taken to hospital. One was treated for non-life-threatening injuries and released. The other male suffered severe head trauma and is in serious condition.

The woman is facing charges of attempted murder.