Jane Creba was shot to death on Dec. 26, 2005, as two groups exchanged gunfire amid a crowd of shoppers on Yonge Street. (Canadian Press)

Two men have pleaded not guilty to all charges against them in connection with a shootout in downtown Toronto on Boxing Day 2005 that left 15-year-old Jane Creba dead and six others injured.

Louis Woodcock, 22, and Tyshaun Barnett, 22, pleaded not guilty on Monday to charges of second-degree murder, attempted murder and aggravated assault.

The two are the last people to be tried in connection with the Dec. 26, 2005, death of the Toronto Grade 9 student. Creba was caught in the crossfire of two feuding groups of young men who exchanged gunfire amid a crowd of shoppers on Yonge Street.

In opening remarks to the five men and seven women on the jury, Crown prosecutor Maurice Gillezeau said he would present evidence that strongly implicates Woodcock and Barnett in Creba's death.

At least three guns were used in the shootout, said Gillezeau, and Woodcock's DNA was all over one of them.

Gillezeau said he will also present phone tap conversations between Barnett, Woodcock and others in which Barnett talks about a gun he fired once before it jammed.

Two men are already serving life prison terms for their roles in Creba's killing.

Jeremiah Valentine, 27, pleaded guilty to second-degree murder on Dec. 22 and was sentenced to life with no chance of parole for 12 years.

Jorrell Simpson-Rowe, 21, was found guilty of second-degree murder, two counts of aggravated assault and five weapons charges last April. Simpson-Rowe, who was 17 at the time of Creba's death, was sentenced to an adult life sentence.

The trial for Woodcock and Barnett continues.