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A screen grab from aerial footage above Hwy. 401 at Shannonville Road shows the fiery scene of a fatal crash involving two tractor-trailers Tuesday afternoon. (CKWS)

A fatal crash involving two tractor-trailers on Hwy. 401 Tuesday caused a large fire at Shannonville Road and resulted in the deaths of both drivers, according to Napanee OPP.

Emergency crews responded to the scene of the accident around 3:30 p.m. The accident closed traffic in both directions due to thick smoke causing poor visibility for motorists.

The 401 eastbound lanes were closed between Deseronto Road and Hwy. 37, and one lane was expected to reopen by 2 a.m. Wednesday morning.

The 401 westbound lanes are closed between Marysville Road and Shannonville Road, and are not expected to reopen until midday Thursday.