A deadly series of events unfolded in north Etobicoke on Sunday, when a TTC bus collided with another vehicle, careened through a parking lot and smashed into the front of a bank.

Toronto police say one person died and others were injured when a bus on the 96 Wilson route collided with a car at Kipling Avenue and Westhumber Boulevard at 6 a.m.

The bus was travelling on Westhumber Boulevard when it collided with a Nissan Altima with three occupants inside. All three people in the car were taken to the trauma centre at Sunnybrook hospital.

TTC bus crash

The bus went through the parking lot of a strip mall before hitting the CIBC building. (Ousama Farag/CBC)

After the collision, the bus continued through the intersection and hit the front of a CIBC building, Const. Clint Stibbe told CBC News.

The bus hit a light standard hard enough to topple it. Police say it then hit a fire hydrant and continued through a parking lot before coming to a stop.

"It is quite a devastating amount of damage in the area," Stibbe said.

Police say the man who died was a passenger in the Altima. The exact number of people injured was not immediately clear from initial reports.

Andy Byford, the TTC's chief executive officer, told reporters that six customers were on board the bus when the crash occurred — some of whom walked off the bus on their own, while others were placed on backboards because of possible spinal injuries.

TTC bus car crash

Three people were in a Nissan Altima when it collided with a TTC bus in Etobicoke early Sunday. One person in the car was killed and two were reported in critical condition in hospital. (Ousama Farag/CBC)

"We want to make sure that they're well looked after," Byford said.

He also offered his condolences to the friends and family of the deceased.

Chirag Patel, who owns the Country Style doughnut shop in the same strip mall as the bank, witnessed the crash.

"I thought [the bus] was going it hit my store, it was going to hit me," he said. "It hit the CIBC bank, the front entrance and I called 911."

Patel said he was talking to 911 when he looked at the car and saw a woman inside who appeared to be unconscious.

"I was in shock," he said.

Byford said police were doing a reconstruction of the accident.

Stibbe said police would be reviewing footage from nearby surveillance cameras, as well as any GPS data and footage from the bus itself.

With a report from the CBC's Natalie Kalata