One man is dead following a nine-vehicle crash in the eastbound express lanes of Highway 401, just east of Avenue Road, on Tuesday afternoon.

Three other people were transported to hospital with non-life threatening injuries, a Toronto EMS spokesperson told CBC News.

Image of crash on EB 401

An image of one of the vehicles involved in the crash on the eastbound Highway 401, which was taken from the westbound lanes of the highway. (Tweeted by @preppieyeti)

According to Ontario Provincial Police, the driver of a loaded dump truck hauling soil lost control of his vehicle, striking several cars before rolling over and spilling its load across the highway at about 4:40 p.m. ET.

The name of the deceased is being withheld until their next of kin can be notified, OPP said. 

The collision remains under investigation by members of the Toronto OPP detachment and OPP's highway safety division. They are advising drivers to avoid the area, and expect closures to affect traffic until about 1 a.m. ET Wednesday morning. 

The stretch where the collision occurred is an extremely busy part of the highway. Statistics on the Ministry of Transportation website from 2010 suggest that nearly 400,000 motorists travel along the Yonge Street-to-Avenue Road stretch each day.