About 350 residents from the Attawapiskat First Nation will be returning home starting Wednesday, according to Emergency Management Ontario.
They were forced from their homes by flooding and sewer backups.
However, EMO said flood threats are receding on the Attawapiskat River.
About 90 residents staying in the northern Ontario town of Greenstone are going home Wednesday.
Another 260 residents will start flying home from Thunder Bay on Thursday.
EMO said 64 residents who were moved to Fort Frances will have to remain there until their homes are cleaned and repaired.
Meanwhile, more than 300 residents from Kashechewan will remain in Kapuskasing until their homes have been cleaned and inspected.