Police say a 42-year-old man from Saskatoon is dead after a fatal highway accident. (CBC)

Police are investigating after a 42-year-old Saskatoon man was killed in a head-on crash between a car and semi truck on Highway 12 Wednesday. 

The northbound semi hauling an unloaded livestock trailer collided with a southbound vehicle at the Petrofka Bridge, about 50 kilometres north of Saskatoon, at about 12 p.m. CST. 

The driver of the vehicle was pronounced dead at the scene. 

The semi caught on fire and was destroyed, but the driver escaped unharmed. 

A stretch of Highway 12 was closed for more than eight hours while police investigated the crash. 

There is no word on what may have caused the crash, but police said they do not believe alcohol was a factor.