RCMP and the Prince Albert Fire Department were called to crash at the intersection of highway 2 and highway 355 on Thursday evening.
The collision was between a blue Windstar van with two occupants inside and a black Pontiac G6 with one.
All of them were taken to hospital.
The passenger of the van was ejected from the vehicle and suffered what RCMP believe to be serious injuries.
The sole occupant of the G6 is believed to have a lower body injury.
Police are still investigating.