Multiple people with undetermined injuries have been sent to hospital in Regina after a crash between a semi, ambulance and other vehicles on Highway 1 near Pense.

Moose Jaw and Regina firefighters remain on scene. RCMP reopened one eastbound lane to traffic at around 5:30 CST. Traffic was backed up for about five kilometres on the highway.

Fire officials say at least six vehicles are involved. The collision became a "chain reaction" on the road, where whiteout conditions are being reported during a winter storm that's hitting the south-central part of the province. 

Because of deteriorating road conditions, motorists are asked to check the provincial Highway Hotline before heading out. 

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Snow blows at the scene on Highway 1 near Pense, where at least six vehicle crashed including a semi and an ambulance. (Goeff Leo/CBC)